Referanslar

• Nishida-Tamehiro K, Kimura A, Tsubata T, Takahashi S, Suzuki H. Antioxidative enzyme NAD(P)H quinone oxidore-ductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels. PLoS One. 2022;17(7):e0272090. doi:10.1371/journal.pone.0272090 google scholar
• Preethi S, Arthiga K, Patil AB, Spandana A, Jain V. Review on NAD(P)H dehydrogenase quinone 1 (NQO1) pathway. Mol Biol Rep. 2022;49(9):8907-8924 google scholar
• Ross D, Siegel D. The diverse functionality of NQO1 and its roles in redox control. Redox Biol. 2021;41:101950. doi:10.1016/j.redox.2021.101950 google scholar
• Beaver SK, Mesa-Torres N, Pey AL, Timson DJ. NQO1: A target for treating cancer and neurological diseases, and a model to understand loss of function disease mechanisms. Biochim Biophys Acta Proteins Proteom. 2019;1867(7-8):663-676. google scholar
• Li X, Liu Z, Zhang A, et al. NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance. Nat Commun. 2019;10(1):3251. doi:10.1038/s41467-019-11238-1 google scholar
• Parkinson EI, Hergenrother PJ. Deoxynyboquinones as NQO1-activated cancer therapeutics. Acc Chem Res. 2015;48(10):2715-2723. google scholar
• Lundberg AP, Francis JM, Pajak M, et al. Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species. Invest New Drugs. 2017;35(2):134-144. google scholar
• Oh ET, Park HJ. Implications of NQO1 in cancer therapy. BMB Rep. 2015;48(11):609-617. google scholar
• Liu Y, Jiang M, Zhao Z, Wang N, Wang K, Yuan Y. Cyclic amplification of intracellular ROS boosts enzymatic prodrug activation for enhanced chemo-immunotherapy. Acta Biomater. 2023;166:567-580. google scholar
• Yang PW, Xu PL, Cheng CS, et al. Integrating network pharmacol-ogy and experimental models to investigate the efficacy of QYHJ on pancreatic cancer. J Ethnopharmacol. 2022;297:115516. doi:10.1016/j.jep.2022.115516 google scholar
• Xia MH, Yan XY, Zhou L, et al. p62 suppressed VK3-induced oxidative damage through Keap1/Nrf2 pathway in human ovarian cancercells. J Cancer. 2020;11(6):1299-1307. google scholar
• Li J, Zhang J, Zhu Y, Afolabi LO, Chen L, Feng X. Natural compounds, optimal combination of brusatol and polydatin pro-mote anti-tumor effect in breast cancer by targeting nrf2 signaling pathway. Int JMol Sci. 2023;24(9). doi:10.3390/îjms24098265 google scholar
• Tsai HY, Bronner MP, March JK, et al. Metabolic targeting of NRF2 potentiates the efficacy of the TRAP1 inhibitor G-TPP through reduction of ROS detoxification in colorectal cancer. Can-cer Lett. 2022;549:215915. doi:10.1016/j.canlet.2022.215915 google scholar
• Ramesh PS, Raja S, Udayakumar SH, Chandrashekar S, Nataraj SM, Devegowda D. Role of NRF2 cascade in determining the differential response of cervical cancer cells to anticancer drugs: An in vitro study. Mol Biol Rep. 2022;49(1):109-119. google scholar
• Bovilla VR, Kuruburu MG, Bettada VG, et al. Targeted inhibi-tion of anti-inflammatory regulator nrf2 results in breast can-cer retardation in vitro and in vivo. Biomedicines. 2021;9(9). doi:10.3390/biomedicines9091119 google scholar
• Ross D, Siegel D. Functions of NQO1 in cellular protec-tion and CoQ(10) metabolism and its potential role as a re-dox sensitive molecular switch. Front Physiol. 2017;8:595. doi:10.3389/fphys.2017.00595 google scholar
• Gong Q, Yang F, Hu J, et al. Rational designed highly sensi-tive NQO1-activated near-infrared fluorescent probe combined with NQO1 substrates in vivo: An innovative strategy for NQO1-overexpressing cancer theranostics. Eur J Med Chem. 2021;224:113707. doi:10.1016/j.ejmech.2021.113707 google scholar
• Zhao W, Jiang L, Fang T, et al. Beta-Lapachone selectively kills hepatocellular carcinoma cells by targeting NQO1 to induce ex-tensive dna damage and PARP1 hyperactivation. Front Oncol. 2021;11:747282. doi:10.3389/fonc.2021.747282 google scholar
• Starcher CL, Pay SL, Singh N, et al. Targeting base ex-cision repair in cancer: NQO1-bioactivatable drugs improve tumor selectivity and reduce treatment toxicity through ra-diosensitization of human cancer. Front Oncol. 2020;10:1575. doi:10.3389/fonc.2020.01575 google scholar
• Pervaiz S. Resveratrol-from the bottle to the bedside? Leuk Lymphoma. 2001;40(5-6):491-498.10428190109097648 google scholar
• Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: A molecule whose time has come? And gone? Clin Biochem. 1997;30(2):91-113. google scholar
• Wright JS, Johnson ER, DiLabio GA. Predicting the activity of phenolic antioxidants: Theoretical method, analysis of substituent effects, and application to major families of antioxidants. J Am Chem Soc. 2001;123(6):1173-1183. google scholar
• Ji Q, Liu X, Han Z, et al. Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-beta1/Smads signaling pathway mediated Snail/E-cadherin ex-pression. BMC Cancer. 2015;15:97. doi:10.1186/s12885-015-1119-y google scholar
• Bian P, Hu W, Liu C, Li L. Resveratrol potentiates the anti-tumor effects of rapamycin in papillary thyroid cancer: PI3K/AKT/mTOR pathway involved. Arch Biochem Biophys. 2020;689:108461. doi:10.1016/j.abb.2020.108461 google scholar
• Hope C, Planutis K, Planutiene M, et al. Low concentrations of resveratrol inhibit Wnt signal throughput in colon-derived cells:Implications for colon cancer prevention. Mol Nutr Food Res. 2008;52 Suppl 1(Suppl 1):S52-61. google scholar
• Ren B, Kwah MX, Liu C, et al. Resveratrol for cancer therapy: Challenges and future perspectives. Cancer Lett. 2021;515:63-72. google scholar
• Morris GM, Huey R, Lindstrom W, et al. AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J Comput Chem. 2009;30(16):2785-2791. google scholar
• Kim S, Chen J, Cheng T, et al. PubChem in 2021: New data content and improved web interfaces. Nucleic Acids Res. 2021;49(D1):388-395. google scholar
• Behera SK, Vhora N, Contractor D, et al. Computational drug repurposing study elucidating simultaneous inhibition of entry and replication of novel corona virus by Grazoprevir. Sci Rep. 2021;11(1):7307. doi:10.1038/s41598-021-86712-2 google scholar
• Durrant JD, McCammon JA. Molecular dynamics simulations and drug discovery. BMC Biol. 2011;9:71. doi:10.1186/1741-7007-9-71 google scholar
• Raghu R, Devaraji V, Leena K, et al. Virtual screening and dis-covery of novel aurora kinase inhibitors. Curr Top Med Chem.2014;14(17):2006-2019. google scholar
• Shivakumar D, Williams J, Wu Y, Damm W, Shelley J, Sherman W. Prediction of absolute solvation free energies using molecular dynamics free energy perturbation and the OPLS force field. J Chem Theory Comput. 2010;6(5):1509-1519. google scholar
• Aier I, Varadwaj PK, Raj U. Structural insights into conforma-tional stability of both wild-type and mutant EZH2 receptor. Sci Rep. 2016;6:34984. doi:10.1038/srep34984 google scholar
• Deniz U, Ozkirimli E, Ulgen KO. A systematic methodology for large scale compound screening: A case study on the discovery of novel S1PL inhibitors. JMol Graph Model. 2016;63:110-124. google scholar
• Behera SK, Mahapatra N, Tripathy CS, Pati S. Drug repurpos-ing for identification of potential inhibitors against SARS-CoV-2 spike receptor-binding domain: An in silico approach. Indian J Med Res. 2021;153(1 & 2):132-143. google scholar
• Pace CN, Fu H, Lee Fryar K, et al. Contribution of hydrogen bonds to protein stability. Protein Sci. 2014;23(5):652-661. google scholar
• Vladilo G, Hassanali A. Hydrogen bonds and life in the universe. Life (Basel). 2018;8(1). doi:10.3390/life8010001 google scholar
• Bissantz C, Kuhn B, Stahl M. A medicinal chemist’s guide to molecular interactions. JMed Chem. 2010;53(14):5061-5084. google scholar
• Chen D, Oezguen N, Urvil P, Ferguson C, Dann SM, Savidge TC. Regulation of protein-ligand binding affinity by hydrogen bond pairing. Sci Adv. 2016;2(3):e1501240. doi:10.1126/sciadv.1501240 google scholar
• Hamelberg D, Mongan J, McCammon JA. Accelerated molec-ular dynamics: Apromising and efficient simulation method for biomolecules. J Chem Phys. 2004;120(24):11919-11929. google scholar
• Ferenczy GG, Kellermayer M. Contribution of hydrophobic inter-actions to protein mechanical stability. Comput Struct Biotechnol J. 2022;20:1946-1956. google scholar
• Dariya B, Behera SK, Srivani G, Farran B, Alam A, Nagaraju GP. Computational analysis of nuclear factor-kappaB and resveratrol in colorectal cancer. J Biomol Struct Dyn. 2021;39(8):2914-2922. google scholar
• Al-Karmalawy AA, Dahab MA, Metwaly AM, et al. Molec-ular docking and dynamics simulation revealed the poten-tial inhibitory activity of ACEIs against SARS-CoV-2 tar-geting the hACE2 receptor. Front Chem. 2021;9:661230. doi:10.3389/fchem.2021.661230 google scholar
• Morris JH, Meng EC, Ferrin TE. Computational tools for the interactive exploration of proteomic and structural data. Mol Cell Proteomics. 2010;9(8):1703-1715. google scholar
• Sliwoski G, Kothiwale S, Meiler J, Lowe EW, Jr. Computational methods in drug discovery. Pharmacol Rev. 2014;66(1):334-395. google scholar
• Sadybekov AV, Katritch V. Computational approaches streamlin-ing drug discovery. Nature. 2023;616(7958):673-685. google scholar
• Du X, Li Y, Xia YL, et al. Insights into protein-ligand interactions: Mechanisms, models, and methods. Int J Mol Sci. 2016;17(2). doi:10.3390/ijms17020144 google scholar
• Nagaraju GP, Farran B, Farren M, et al. Napabucasin (BBI 608), a potent chemoradiosensitizer in rectal cancer. Cancer. 2020;126(14):3360-3371. google scholar

Atıflar