Referanslar

• 1 Lipps BV Novel snake venom protein cytolytic to cancer cells in vitro and in vivo systems J Venom Anim Toxins 1999; 5: 172-83 google scholar
• 2 Szakacs G, Paterson JK, Ludwig JA, Genthe CB, Gottesman MM Tar-geting multidrug resistance in Cancer Nat Rev Drug Discov 2006; 5: 219-34 google scholar
• 3 Kocdogan K Meme Kanserli Hastalarda Glutatyon S-Trensferaz Izozim-lerin Coklu Ilaç Direnç Mekanizmasındaki Proteinlerle Olan Ilişkilerin Incelenmesi K Ü Fen Bilimleri Enstitüsü, Yüksek Lisans Tezi 2016 google scholar
• 4 Cheng D, Dattaro JA, Yakobi R, Bush SP, Gerardo CJ Scorpion en-venomation Medscape 2011 Sep Available from: URL: http:// emedicine medscape com/ article/168230-overview google scholar
• 5 Ozkan O, Carhan A The neutralizing capacity of Androctonus cras-sicauda antivenom against Mesobuthus eupeus scorpion venom Toxicon 2008; 52: 375-9 google scholar
• 6 Gurevitz M, Karbat I, Cohen L, Ilan N, Kahn R, Turkov M, Stankiewicz, M, Stühmer W, Dong K, Gordon D The insecticidal potential of scorpion 0-toxins .Toxicon 2007; 49:473-89. google scholar
• 7. Park J, Cho SY, Choi SJ. Purification and characterization of hepatic lipase from Todarodes pacificus. BMB reports 2008; 41: 254-8. google scholar
• 8. Raposo C. Scorpion and spider venoms in cancer treatment: state of the art, challenges, and perspectives. J Clin Transl Res 2017; 24: 233-49. google scholar
• 9. Gopalakrishnakone P, Cheah J, Gwee MCE. Black scorpion (Het-erometrus longimanus) as a laboratory animal: maintenance of a colony of scorpion for milking of venom for research, using a re-straining device. Lab Anim 1995; 29: 456-8. google scholar
• 10. Oukkache N, Chgoury F, Lalaoui M, Cano A A, Ghalim N. Compari-son between two methods of scorpion venom milking in Morocco. J Venom Anim Toxins Incl Trop Dis 2013; 19: 5-8. google scholar
• 11. Tobassum S, Tahir HM, Zahid MT, Gardner QA, Ahsan MM. Effect of milking method, diet, and temperature on venom production in scorpions. J Insect Sci 2018; 18: 19-21. google scholar
• 12. du Plessis JL. Collection of venom from southern African scorpi-ons. Toxicon 2005; 45: 681-2. google scholar
• 13. Diniz CR. Chemical and pharmacological aspects of Tityinae ven-oms. Arthropod venoms. Berlin: Springer-Verlag, 1978, 379-94. google scholar
• 14. Willems J, Noppe W, Moerman L, Van der WJ, Verdonck F. Cationic peptides from scorpion venom can stimulate and inhibit polymor-phonuclear granulocytes. Toxicon 2002; 40: 1679-83. google scholar
• 15. Xiong Y, Lan Z, Wang M, Liu B, Liu X, Fei H, et al. Molecular charac-terization of new excitatory insect neurotoxin with an analgesic effect on mice from the scorpion Buthus martensii Karsch. Toxicon 1999; 37: 1165-80. google scholar
• 16. Mortari MR, Cunha AOS, Ferreira LB, Ferreira dos Santos W. Neuro-toxins from invertebrates as anticonvulsants: From basic research to therapeutic application. Pharmacol Ther 2007; 114: 171-83. google scholar
• 17. Chen Y, Cao L, Zhong M, Zhang Y, Han C, Li Q, et al. Anti-HIV-1 activ-ity of a new scorpion venom peptide derivative Kn2-7. PLoS One 2012; 7: e34947. google scholar
• 18. Zhijian C, Feng L, Yingliang W, Xin M, Wenxin L. Genetic mechanisms of scorpion venom peptide diversification. Toxicon 2006; 47: 348-55. google scholar
• 19. Ammar A, Qosay A. Scorpion venom peptides with no disulfide bridges: A review. Peptides 2014; 51: 35-45. google scholar
• 20. Yu FH, Catterall WA. Overview of the voltage-gated sodium chan-nel family. Genome Biol 2003; 4(3): 1-7. google scholar
• 21. Possani LD, Merino E, Corona M, Bolivar F, Becerril B. Peptides and genes coding for scorpion toxins that affect ion-channels. Bio-chimie 2000; 82(9): 861-8. google scholar
• 22. Cestele S, Catterall WA. Molecular mechanisms of neurotoxin ac-tion on voltage-gated sodium channels. Biochimie 2000; 82(9): 883-92. google scholar
• 23. Shieh CC, Coghlan M, Sullivan JP, Gopalakrishnan M. Potassium channels: molecular defects, diseases, and therapeutic opportuni-ties. Pharmacol Rev 2000; 52 (4): 557-94. google scholar
• 24. Catterall WA. Cellular and molecular biology of voltage-gated so-dium channels. Physiol Rev 1992; 72(4): 15-48. google scholar
• 25. Cid-Uribe JI, Veytia-Bucheli JI, Romero-Gutierrez T, Ortiz E, Possani LD. Scorpion venomics: a 2019 overview. Expert Rev Proteomics 2020; 7(1): 67-83. google scholar
• 26. Tossi A, Sandri L, Giangaspero A. Amphipathic, a-helical antimicro-bial peptides. Biopolymers 2000; 55: 4-30. google scholar
• 27. Bradford MM. Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of pro-tein-dye binding. Anal Biochem 1976; 72: 248-54. google scholar
• 28. Kelle I. Terapötik potansiyele sahip venom peptidleri. Dicle Med J 2006; 33: 113 - 26. google scholar
• 29. Çalışkan F, Sivas H, Şahin Y. Purification of Ac8, Ac9 and Ac10 peptıdes from Androctonus crassicauda crude venom with cyto-toxic effect on Bc3h1 cells. Anadolu Univ J of Sci and Technology -A-Appl Sciand Eng 2009;10(2):515-24. google scholar
• 30. Omran MAA. Cytotoxic and apoptotic effects of scorpion Leiurus quinquestriatus venom on 293T and C2C12 eukaryotic cell lines. J Venom Anim Toxins Incl Trop Dis 2003; 9:255-76. google scholar
• 31. Fu YJ, Yin LT, Liang AH, Zhang CF, Wang W, Chai BF, et al. Therapeu-tic potential of chlorotoxin-like neurotoxin from the Chinese scor-pion for human gliomas. Neurosci Lett 2007; 412 (1): 62-7. google scholar
• 32. Veiseh M, Gabikian P, Bahrami SB. Tumor paint: a cholorotoxin: L Cy5.5 bioconjugate for interaoperative visualization of cancer foci. Cancer Research 2007; 67: 6882-8. google scholar
• 33. Kesavan K, Ratliff J, Johnson EW, Dahlberg W, Asara JM, Misra P. Annexin A2 is a molecular target for TM601, a peptide with tu-mor-targeting and anti-angiogenic effects. J Biol Chem 2010; 285: 4366-74. google scholar
• 34. Sun C, Stephen Z, Veiseh O, Harisen S, Lee D, Ellenbogen RG, et al. Tumor targeted drug delivery and MRI contrast enhancement by chlorotoxin conjugated iron oxide nanoparticle. Nanomed 2008; 3: 495-505. google scholar
• 35. Wang WX, Ji YH. Scorpion venom induces glioma cell apoptosis in vivo and inhibits glioma tumor growth in vitro. J Neuro-Oncol 2005; 73(1): 1-7. google scholar
• 36. Gupta SD, Gomes A, Debnath A, Saha A, Gomes A. Apoptosis in-duction in human leukemic cells by a novel protein bengalin, iso-lated from Indian black scorpion venom: through mitochondrial pathway and inhibition of heat shock proteins. Chem Biol Interact 2010; 183(2): 293-303. google scholar
• 37. Hayden MS, West AP, Ghosh S. NF-kappaB and the immune re-sponse. Oncogene 2006; 25: 6758-80. google scholar
• 38. Zhang YY, Wu LC, Wang ZP, Wang ZX, Jia Q, Jiang GS, et al. Anti-pro-liferation effect of polypeptide extracted from scorpion venom on human prostate cancer cells in vitro. J Clin Med Res 2009; 1(1): 24-3. google scholar
• 39. Feng L, Gao R, Gopalakrishnakone P. Isolation and characterization of a hyaluronidase from the venom of Chinese red scorpion Buthus martensi. Comp Biochem Physiol C Toxicol Pharmacol 2008; 148: 250-7. google scholar
• 40. Sariego J. Breast cancer in the young patient. Am Surg 2010; 76:1397-401. google scholar
• 41. Pessini AC, Takao TT, Cavalheiro EC, Vichnewski W, Sampaio SV, Giglio JR, et al. A hyaluronidase from Tityus serrulatus scorpion venom: isolation, characterization and inhibition by flavonoids. Toxicon 2001; 39: 1495-504. google scholar
• 42. Norberg E, Orrenius S, Zhivotovsky B. Mitochondrial regulation of cell death: Processing of apoptosis-inducing factor (AIF). Biochem Biophy Res Comm 2010; 396: 95-100. google scholar

Atıflar