Myrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation
Fatma Kanpalta, Büşra Ertaş, Ali Şen, Dilek Akakın, Göksel Şener, Feriha ErcanObjective: Obesity is associated with many diseases, including urinary system disorders such as chronic kidney disease and overactive bladder syndrome. Myrtus communis L. (MC) extract has been reported to have antioxidant and anti-inflammatory effects. The aim of this study was to investigate the protective effects of MC extract on high-fat diet (HFD)-induced kidney and bladder damage. Materials and Methods: Wistar albino male rats were divided into three experimental groups: control, HFD and HFD+MC. Experimental groups were fed a standard diet (control group) or HFD (HFD and HFD+MC groups) for 16 weeks. MC extract (100 mg/kg) was administered to the HFD+MC group orally during the last 4 weeks (5 days/week) of the experiment. Highdensity lipoprotein, total cholesterol, triglyceride and leptin levels were measured in blood serum. Tissue malondialdehyde (MDA), glutathione (GSH), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and myeloperoxidase (MPO) levels were evaluated biochemically. Kidney and bladder morphology, NADPH oxidase-2 (NOX-2) and nuclear factor-kappa B (NF-ҡB)-positive and apoptotic cells were evaluated histologically. Results: Lipid profiles altered and leptin levels increased in blood serum. MDA, 8-OHdG and MPO levels increased and GSH level decreased in kidney and bladder in the HFD group. Moreover, degenerated kidney and bladder morphology, increased NOX-2 and NF-ҡB-positive and apoptotic cells were observed in this group. All of these biochemical and histological parameters were ameliorated in the HFD+MC group. Conclusion: HFD-induced obesity causes kidney and bladder damage by oxidative and inflammatory processes. MC extract may reduce oxidative stress and inflammation and play a protective role in obesity-related kidney and bladder damage.
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APA
Kanpalta, F., Ertaş, B., Şen, A., Akakın, D., Şener, G., & Ercan, F. (2022). Myrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation. European Journal of Biology, 81(2), 217-230. https://doi.org/10.26650/EurJBiol.2022.1111191
AMA
Kanpalta F, Ertaş B, Şen A, Akakın D, Şener G, Ercan F. Myrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation. European Journal of Biology. 2022;81(2):217-230. https://doi.org/10.26650/EurJBiol.2022.1111191
ABNT
Kanpalta, F.; Ertaş, B.; Şen, A.; Akakın, D.; Şener, G.; Ercan, F. Myrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation. European Journal of Biology, [Publisher Location], v. 81, n. 2, p. 217-230, 2022.
Chicago: Author-Date Style
Kanpalta, Fatma, and Büşra Ertaş and Ali Şen and Dilek Akakın and Göksel Şener and Feriha Ercan. 2022. “Myrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation.” European Journal of Biology 81, no. 2: 217-230. https://doi.org/10.26650/EurJBiol.2022.1111191
Chicago: Humanities Style
Kanpalta, Fatma, and Büşra Ertaş and Ali Şen and Dilek Akakın and Göksel Şener and Feriha Ercan. “Myrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation.” European Journal of Biology 81, no. 2 (Nov. 2024): 217-230. https://doi.org/10.26650/EurJBiol.2022.1111191
Harvard: Australian Style
Kanpalta, F & Ertaş, B & Şen, A & Akakın, D & Şener, G & Ercan, F 2022, 'Myrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation', European Journal of Biology, vol. 81, no. 2, pp. 217-230, viewed 22 Nov. 2024, https://doi.org/10.26650/EurJBiol.2022.1111191
Harvard: Author-Date Style
Kanpalta, F. and Ertaş, B. and Şen, A. and Akakın, D. and Şener, G. and Ercan, F. (2022) ‘Myrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation’, European Journal of Biology, 81(2), pp. 217-230. https://doi.org/10.26650/EurJBiol.2022.1111191 (22 Nov. 2024).
MLA
Kanpalta, Fatma, and Büşra Ertaş and Ali Şen and Dilek Akakın and Göksel Şener and Feriha Ercan. “Myrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation.” European Journal of Biology, vol. 81, no. 2, 2022, pp. 217-230. [Database Container], https://doi.org/10.26650/EurJBiol.2022.1111191
Vancouver
Kanpalta F, Ertaş B, Şen A, Akakın D, Şener G, Ercan F. Myrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation. European Journal of Biology [Internet]. 22 Nov. 2024 [cited 22 Nov. 2024];81(2):217-230. Available from: https://doi.org/10.26650/EurJBiol.2022.1111191 doi: 10.26650/EurJBiol.2022.1111191
ISNAD
Kanpalta, Fatma - Ertaş, Büşra - Şen, Ali - Akakın, Dilek - Şener, Göksel - Ercan, Feriha. “Myrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation”. European Journal of Biology 81/2 (Nov. 2024): 217-230. https://doi.org/10.26650/EurJBiol.2022.1111191