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DOI :10.26650/EurJBiol.2025.1568086   IUP :10.26650/EurJBiol.2025.1568086    Tam Metin (PDF)

Protective Effects of Cuscuta sp. against Cardiorenal Injury in Bile Duct-Ligated Rats

Bilge Nur HatipoğluDilek ÖzbeyliAli ŞenÖzge ÇevikFeriha ErcanÖmercan AlbayrakSeren Ede PazarbaşıFatma Kanpalta MustafaoğluGöksel Şener

Objective: Bile duct ligation (BDL) obstructs bile flow, resulting in bile and toxic substances buildup that causes liver damage. This study investigated the protective effects of Cuscuta sp. methanol extract (CUS) against cardiorenal injury in bile duct-ligated rats.

Materials and Methods: Rats were categorised into four groups: Control (C), CUS, BDL, and BDL+CUS. The C and BDL groups received saline, whereas the other groups received oral 250 mg/kg CUS. After 28 days, blood, kidney, and heart tissue samples were collected for biochemical and histological analyses. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), direct bilirubin (DB), and total bilirubin (TB) levels were analysed to determine liver function, while Transforming growth factor-beta (TGF-β) and hydroxyproline (HYP) levels were evaluated for fibrosis, and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels alongside Na⁺/K⁺-ATPase activity were analysed to assess oxidative stress and membrane injury in the heart and renal tissues.

Results: AST, ALT, DB, and TB levels were significantly elevated in the BDL group compared with the C group; however, the levels were distinctly lower in the BDL+CUS group than in the BDL group. Additionally, in both tissues, TGF-β, HYP, and 8-OHdG levels were higher in the BDL group than in the C group, but decreased in the BDL+CUS group, with Na⁺/K⁺-ATPase activity being lower in BDL group compared with the C group and significantly increased in BDL+CUS group.

Conclusion: CUS has protective effects against oxidative damage and offers antioxidant and anti-inflammatory benefits against cholestasis-induced tissue injury. 


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DIŞA AKTAR



APA

Hatipoğlu, B.N., Özbeyli, D., Şen, A., Çevik, Ö., Ercan, F., Albayrak, Ö., Ede Pazarbaşı, S., Kanpalta Mustafaoğlu, F., & Şener, G. (2019). Protective Effects of Cuscuta sp. against Cardiorenal Injury in Bile Duct-Ligated Rats. European Journal of Biology, 0(0), -. https://doi.org/10.26650/EurJBiol.2025.1568086


AMA

Hatipoğlu B N, Özbeyli D, Şen A, Çevik Ö, Ercan F, Albayrak Ö, Ede Pazarbaşı S, Kanpalta Mustafaoğlu F, Şener G. Protective Effects of Cuscuta sp. against Cardiorenal Injury in Bile Duct-Ligated Rats. European Journal of Biology. 2019;0(0):-. https://doi.org/10.26650/EurJBiol.2025.1568086


ABNT

Hatipoğlu, B.N.; Özbeyli, D.; Şen, A.; Çevik, Ö.; Ercan, F.; Albayrak, Ö.; Ede Pazarbaşı, S.; Kanpalta Mustafaoğlu, F.; Şener, G. Protective Effects of Cuscuta sp. against Cardiorenal Injury in Bile Duct-Ligated Rats. European Journal of Biology, [Publisher Location], v. 0, n. 0, p. -, 2019.


Chicago: Author-Date Style

Hatipoğlu, Bilge Nur, and Dilek Özbeyli and Ali Şen and Özge Çevik and Feriha Ercan and Ömercan Albayrak and Seren Ede Pazarbaşı and Fatma Kanpalta Mustafaoğlu and Göksel Şener. 2019. “Protective Effects of Cuscuta sp. against Cardiorenal Injury in Bile Duct-Ligated Rats.” European Journal of Biology 0, no. 0: -. https://doi.org/10.26650/EurJBiol.2025.1568086


Chicago: Humanities Style

Hatipoğlu, Bilge Nur, and Dilek Özbeyli and Ali Şen and Özge Çevik and Feriha Ercan and Ömercan Albayrak and Seren Ede Pazarbaşı and Fatma Kanpalta Mustafaoğlu and Göksel Şener. Protective Effects of Cuscuta sp. against Cardiorenal Injury in Bile Duct-Ligated Rats.” European Journal of Biology 0, no. 0 (Mar. 2025): -. https://doi.org/10.26650/EurJBiol.2025.1568086


Harvard: Australian Style

Hatipoğlu, BN & Özbeyli, D & Şen, A & Çevik, Ö & Ercan, F & Albayrak, Ö & Ede Pazarbaşı, S & Kanpalta Mustafaoğlu, F & Şener, G 2019, 'Protective Effects of Cuscuta sp. against Cardiorenal Injury in Bile Duct-Ligated Rats', European Journal of Biology, vol. 0, no. 0, pp. -, viewed 10 Mar. 2025, https://doi.org/10.26650/EurJBiol.2025.1568086


Harvard: Author-Date Style

Hatipoğlu, B.N. and Özbeyli, D. and Şen, A. and Çevik, Ö. and Ercan, F. and Albayrak, Ö. and Ede Pazarbaşı, S. and Kanpalta Mustafaoğlu, F. and Şener, G. (2019) ‘Protective Effects of Cuscuta sp. against Cardiorenal Injury in Bile Duct-Ligated Rats’, European Journal of Biology, 0(0), pp. -. https://doi.org/10.26650/EurJBiol.2025.1568086 (10 Mar. 2025).


MLA

Hatipoğlu, Bilge Nur, and Dilek Özbeyli and Ali Şen and Özge Çevik and Feriha Ercan and Ömercan Albayrak and Seren Ede Pazarbaşı and Fatma Kanpalta Mustafaoğlu and Göksel Şener. Protective Effects of Cuscuta sp. against Cardiorenal Injury in Bile Duct-Ligated Rats.” European Journal of Biology, vol. 0, no. 0, 2019, pp. -. [Database Container], https://doi.org/10.26650/EurJBiol.2025.1568086


Vancouver

Hatipoğlu BN, Özbeyli D, Şen A, Çevik Ö, Ercan F, Albayrak Ö, Ede Pazarbaşı S, Kanpalta Mustafaoğlu F, Şener G. Protective Effects of Cuscuta sp. against Cardiorenal Injury in Bile Duct-Ligated Rats. European Journal of Biology [Internet]. 10 Mar. 2025 [cited 10 Mar. 2025];0(0):-. Available from: https://doi.org/10.26650/EurJBiol.2025.1568086 doi: 10.26650/EurJBiol.2025.1568086


ISNAD

Hatipoğlu, BilgeNur - Özbeyli, Dilek - Şen, Ali - Çevik, Özge - Ercan, Feriha - Albayrak, Ömercan - Ede Pazarbaşı, Seren - Kanpalta Mustafaoğlu, Fatma - Şener, Göksel. Protective Effects of Cuscuta sp. against Cardiorenal Injury in Bile Duct-Ligated Rats”. European Journal of Biology 0/0 (Mar. 2025): -. https://doi.org/10.26650/EurJBiol.2025.1568086



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