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DOI :10.26650/IstanbulJPharm.2024.1385630   IUP :10.26650/IstanbulJPharm.2024.1385630    Tam Metin (PDF)

Antimicrobial activities of Scorzonera ketzkhowelii Sosn. ex Grossh. (Asteraceae) and determination of natural compounds by LC-HRMS analysis

Fatma GöçAynur SarıBekir ÖzerSerdar MakbulKamil Coşkunçelebi

Background and Aims: Scorzonera ketzkhowelii Sosn. ex Grossh. (Asteraceae) was reported as a new species in the Flora of Turkey in 2010. However, there have been no prior biological or chemical investigations conducted.

Methods: This study aims to investigate the antimicrobial activities of the petroleum ether, dichloromethane, ethyl acetate, and n-butanol fractions derived from S. ketzkhowelii, and determination of secondary metabolites by Liquid Chromatography with High Resolution Mass Spectrometry (LC-HRMS) analysis on the most active antimicrobial fractions.

Results: Notably, all of the fractions demonstrated antimicrobial activity against selected microorganisms, with the dichloromethane fraction of the aerial part exhibiting a higher inhibition of microbial growth compared to the other extracts. The findings of our study revealed the presence of several phenolic compounds in the dichloromethane fractions from both the aerial and subaerial parts, including 3,4-dihydroxybenzaldehyde, salicylic acid, dihydrocaffeic acid, caffeic acid, caffeic acid phenethyl ester, chlorogenic acid, quercetin, hyperoside, naringenin, apigenin, hispidulin, hispidulin 7-glucoside, chrycin, emodin, and carnosic acid. Furthermore, dichloromethane fraction of the aerial parts contained additional phenolic compounds such as homogentisic acid, verbascoside, (+)-trans taxifolin, apigenin 7-glucoside, luteolin, orientin, and chrysoeriol.

Conclusion: The plant’s demonstrated antimicrobial attributes and the diverse range of phenolic compounds it contains present it as a promising subject for continued research and potential applications within the realms of medicine and pharmaceuticals. Further exploration of its bioactivity and potential health benefits may reveal novel avenues for its practical utilization.


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APA

Göç, F., Sarı, A., Özer, B., Makbul, S., & Coşkunçelebi, K. (2024). Antimicrobial activities of Scorzonera ketzkhowelii Sosn. ex Grossh. (Asteraceae) and determination of natural compounds by LC-HRMS analysis. İstanbul Journal of Pharmacy, 54(1), 61-68. https://doi.org/10.26650/IstanbulJPharm.2024.1385630


AMA

Göç F, Sarı A, Özer B, Makbul S, Coşkunçelebi K. Antimicrobial activities of Scorzonera ketzkhowelii Sosn. ex Grossh. (Asteraceae) and determination of natural compounds by LC-HRMS analysis. İstanbul Journal of Pharmacy. 2024;54(1):61-68. https://doi.org/10.26650/IstanbulJPharm.2024.1385630


ABNT

Göç, F.; Sarı, A.; Özer, B.; Makbul, S.; Coşkunçelebi, K. Antimicrobial activities of Scorzonera ketzkhowelii Sosn. ex Grossh. (Asteraceae) and determination of natural compounds by LC-HRMS analysis. İstanbul Journal of Pharmacy, [Publisher Location], v. 54, n. 1, p. 61-68, 2024.


Chicago: Author-Date Style

Göç, Fatma, and Aynur Sarı and Bekir Özer and Serdar Makbul and Kamil Coşkunçelebi. 2024. “Antimicrobial activities of Scorzonera ketzkhowelii Sosn. ex Grossh. (Asteraceae) and determination of natural compounds by LC-HRMS analysis.” İstanbul Journal of Pharmacy 54, no. 1: 61-68. https://doi.org/10.26650/IstanbulJPharm.2024.1385630


Chicago: Humanities Style

Göç, Fatma, and Aynur Sarı and Bekir Özer and Serdar Makbul and Kamil Coşkunçelebi. Antimicrobial activities of Scorzonera ketzkhowelii Sosn. ex Grossh. (Asteraceae) and determination of natural compounds by LC-HRMS analysis.” İstanbul Journal of Pharmacy 54, no. 1 (Nov. 2024): 61-68. https://doi.org/10.26650/IstanbulJPharm.2024.1385630


Harvard: Australian Style

Göç, F & Sarı, A & Özer, B & Makbul, S & Coşkunçelebi, K 2024, 'Antimicrobial activities of Scorzonera ketzkhowelii Sosn. ex Grossh. (Asteraceae) and determination of natural compounds by LC-HRMS analysis', İstanbul Journal of Pharmacy, vol. 54, no. 1, pp. 61-68, viewed 15 Nov. 2024, https://doi.org/10.26650/IstanbulJPharm.2024.1385630


Harvard: Author-Date Style

Göç, F. and Sarı, A. and Özer, B. and Makbul, S. and Coşkunçelebi, K. (2024) ‘Antimicrobial activities of Scorzonera ketzkhowelii Sosn. ex Grossh. (Asteraceae) and determination of natural compounds by LC-HRMS analysis’, İstanbul Journal of Pharmacy, 54(1), pp. 61-68. https://doi.org/10.26650/IstanbulJPharm.2024.1385630 (15 Nov. 2024).


MLA

Göç, Fatma, and Aynur Sarı and Bekir Özer and Serdar Makbul and Kamil Coşkunçelebi. Antimicrobial activities of Scorzonera ketzkhowelii Sosn. ex Grossh. (Asteraceae) and determination of natural compounds by LC-HRMS analysis.” İstanbul Journal of Pharmacy, vol. 54, no. 1, 2024, pp. 61-68. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2024.1385630


Vancouver

Göç F, Sarı A, Özer B, Makbul S, Coşkunçelebi K. Antimicrobial activities of Scorzonera ketzkhowelii Sosn. ex Grossh. (Asteraceae) and determination of natural compounds by LC-HRMS analysis. İstanbul Journal of Pharmacy [Internet]. 15 Nov. 2024 [cited 15 Nov. 2024];54(1):61-68. Available from: https://doi.org/10.26650/IstanbulJPharm.2024.1385630 doi: 10.26650/IstanbulJPharm.2024.1385630


ISNAD

Göç, Fatma - Sarı, Aynur - Özer, Bekir - Makbul, Serdar - Coşkunçelebi, Kamil. Antimicrobial activities of Scorzonera ketzkhowelii Sosn. ex Grossh. (Asteraceae) and determination of natural compounds by LC-HRMS analysis”. İstanbul Journal of Pharmacy 54/1 (Nov. 2024): 61-68. https://doi.org/10.26650/IstanbulJPharm.2024.1385630



ZAMAN ÇİZELGESİ


Gönderim03.11.2023
Kabul10.01.2024
Çevrimiçi Yayınlanma30.04.2024

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