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DOI :10.26650/IstanbulJPharm.2019.18010   IUP :10.26650/IstanbulJPharm.2019.18010    Tam Metin (PDF)

Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease

Hülya Yılmaz AydoğanSerap İlikayEnder CoşkunpınarÖzlem Kurnaz GömleksizZehra BuğraAllison P. EronatOğuz Öztürk

Caveolin-1 (CAV-1) plays a crucial role in endothelial-nitric oxide synthase (eNOS) enzymatic activity. Therefore, CAV-1 and eNOS interactions have a significant impact on endothelial dysfunction, cholesterol levels, and atherosclerosis. We investigated the critical variations in NOS3 and CAV1 genes in this case–control study to determine the relations between the coronary heart disease (CHD) risk factors. The NOS3-rs1799983, CAV-1 rs3840634, and rs3807990 variations were analyzed in 76 CHD patients and 91 controls using the polymerase chain reaction. Mean serum Total-cholesterol levels were significantly higher in CHD patients with the CAV-1 rs3807990-T allele than in patients with CC genotype (p=0.017). There was a statistically significant correlation between the rs3807990-T allele and hypercholesterolemia in the CHD group (p=0.008). The multivariate analysis confirmed that the CAV-1 rs3807990-T allele (p=0.011) is a risk factor for hypercholesterolemia. Moreover, the serum HDL-Cholesterol level was detected to be higher in patients carrying both CAV1-rs3807990-T and NOS3-rs1799983-T alleles than those with the CAV-1 rs3807990-CC/ NOS3-rs1799983-GG genotype subgroup (p=0.013). These results suggested that the genetic variations of CAV-1 rs3807990 and NOS3-rs1799983 may contribute to the increased hypercholesterolemia risk and thus on the development of CHD.  

Anahtar Kelimeler: Cav1NOS3genehypercholesterolemialipidCHD

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APA

Yılmaz Aydoğan, H., İlikay, S., Coşkunpınar, E., Kurnaz Gömleksiz, Ö., Buğra, Z., Eronat, A., & Öztürk, O. (0001). Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease. İstanbul Journal of Pharmacy, 49(2), 53-60. https://doi.org/10.26650/IstanbulJPharm.2019.18010


AMA

Yılmaz Aydoğan H, İlikay S, Coşkunpınar E, Kurnaz Gömleksiz Ö, Buğra Z, Eronat A, Öztürk O. Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease. İstanbul Journal of Pharmacy. 0001;49(2):53-60. https://doi.org/10.26650/IstanbulJPharm.2019.18010


ABNT

Yılmaz Aydoğan, H.; İlikay, S.; Coşkunpınar, E.; Kurnaz Gömleksiz, Ö.; Buğra, Z.; Eronat, A.; Öztürk, O. Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease. İstanbul Journal of Pharmacy, [Publisher Location], v. 49, n. 2, p. 53-60, 0001.


Chicago: Author-Date Style

Yılmaz Aydoğan, Hülya, and Serap İlikay and Ender Coşkunpınar and Özlem Kurnaz Gömleksiz and Zehra Buğra and Allison P. Eronat and Oğuz Öztürk. 0001. “Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease.” İstanbul Journal of Pharmacy 49, no. 2: 53-60. https://doi.org/10.26650/IstanbulJPharm.2019.18010


Chicago: Humanities Style

Yılmaz Aydoğan, Hülya, and Serap İlikay and Ender Coşkunpınar and Özlem Kurnaz Gömleksiz and Zehra Buğra and Allison P. Eronat and Oğuz Öztürk. Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease.” İstanbul Journal of Pharmacy 49, no. 2 (Nov. 2024): 53-60. https://doi.org/10.26650/IstanbulJPharm.2019.18010


Harvard: Australian Style

Yılmaz Aydoğan, H & İlikay, S & Coşkunpınar, E & Kurnaz Gömleksiz, Ö & Buğra, Z & Eronat, A & Öztürk, O 0001, 'Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease', İstanbul Journal of Pharmacy, vol. 49, no. 2, pp. 53-60, viewed 25 Nov. 2024, https://doi.org/10.26650/IstanbulJPharm.2019.18010


Harvard: Author-Date Style

Yılmaz Aydoğan, H. and İlikay, S. and Coşkunpınar, E. and Kurnaz Gömleksiz, Ö. and Buğra, Z. and Eronat, A. and Öztürk, O. (0001) ‘Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease’, İstanbul Journal of Pharmacy, 49(2), pp. 53-60. https://doi.org/10.26650/IstanbulJPharm.2019.18010 (25 Nov. 2024).


MLA

Yılmaz Aydoğan, Hülya, and Serap İlikay and Ender Coşkunpınar and Özlem Kurnaz Gömleksiz and Zehra Buğra and Allison P. Eronat and Oğuz Öztürk. Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease.” İstanbul Journal of Pharmacy, vol. 49, no. 2, 0001, pp. 53-60. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2019.18010


Vancouver

Yılmaz Aydoğan H, İlikay S, Coşkunpınar E, Kurnaz Gömleksiz Ö, Buğra Z, Eronat A, Öztürk O. Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease. İstanbul Journal of Pharmacy [Internet]. 25 Nov. 2024 [cited 25 Nov. 2024];49(2):53-60. Available from: https://doi.org/10.26650/IstanbulJPharm.2019.18010 doi: 10.26650/IstanbulJPharm.2019.18010


ISNAD

Yılmaz Aydoğan, Hülya - İlikay, Serap - Coşkunpınar, Ender - Kurnaz Gömleksiz, Özlem - Buğra, Zehra - Eronat, Allison P. - Öztürk, Oğuz. Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease”. İstanbul Journal of Pharmacy 49/2 (Nov. 2024): 53-60. https://doi.org/10.26650/IstanbulJPharm.2019.18010



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Kabul02.04.2019

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