İstanbul Journal of Pharmacy

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DOI :10.26650/IstanbulJPharm.2019.0076   IUP :10.26650/IstanbulJPharm.2019.0076    Tam Metin (PDF)

Tyrosinase, cholinesterase inhibitory activity and molecular docking studies on apigenin and vitexin

Esen Sezen Karaoğlan, Mehmet Koca

Background and Aims: Apigenin and viteksin are two phytochemical compounds in flavone structure. In this study, tyrosinase and cholinesterase inhibitory effects of apigenin and vitexin were tested. Then, molecular docking studies were conducted on these molecules. Methods: Cholinesterase inhibition was evaluated by minor modifications of Ellman’s method and tyrosinase inhibition was evaluated by minor modifications of Masuda’s method. Docking simulations were performed using the Schrödinger software suite. Results: When apigenin and vitexin were compared, apigenin showed higher inhibitory effect against butyrylcholinesterase (54±1.7%) and tyrosinase (49.36±0.24%), vitexin showed a higher inhibitory effect against acetylcholinesterase (66±1.6%). Conclusion: When molecular interactions between tested compounds and inhibited enzymes were examined, it was observed that there were interactions especially between enzyme structures and benzopyran rings of these compounds and hydroxyl groups bound to these rings.

Anahtar Kelimeler: Apigenin, vitexin, enzyme inhibitory activity, molecular simulation

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DIŞA AKTAR



APA

Sezen Karaoğlan, E., & Koca, M. (2020). Tyrosinase, cholinesterase inhibitory activity and molecular docking studies on apigenin and vitexin. İstanbul Journal of Pharmacy, 50(3), 268-271. https://doi.org/10.26650/IstanbulJPharm.2019.0076


AMA

Sezen Karaoğlan E, Koca M. Tyrosinase, cholinesterase inhibitory activity and molecular docking studies on apigenin and vitexin. İstanbul Journal of Pharmacy. 2020;50(3):268-271. https://doi.org/10.26650/IstanbulJPharm.2019.0076


ABNT

Sezen Karaoğlan, E.; Koca, M. Tyrosinase, cholinesterase inhibitory activity and molecular docking studies on apigenin and vitexin. İstanbul Journal of Pharmacy, [Publisher Location], v. 50, n. 3, p. 268-271, 2020.


Chicago: Author-Date Style

Sezen Karaoğlan, Esen, and Mehmet Koca. 2020. “Tyrosinase, cholinesterase inhibitory activity and molecular docking studies on apigenin and vitexin.” İstanbul Journal of Pharmacy 50, no. 3: 268-271. https://doi.org/10.26650/IstanbulJPharm.2019.0076


Chicago: Humanities Style

Sezen Karaoğlan, Esen, and Mehmet Koca. “Tyrosinase, cholinesterase inhibitory activity and molecular docking studies on apigenin and vitexin.” İstanbul Journal of Pharmacy 50, no. 3 (Apr. 2025): 268-271. https://doi.org/10.26650/IstanbulJPharm.2019.0076


Harvard: Australian Style

Sezen Karaoğlan, E & Koca, M 2020, 'Tyrosinase, cholinesterase inhibitory activity and molecular docking studies on apigenin and vitexin', İstanbul Journal of Pharmacy, vol. 50, no. 3, pp. 268-271, viewed 25 Apr. 2025, https://doi.org/10.26650/IstanbulJPharm.2019.0076


Harvard: Author-Date Style

Sezen Karaoğlan, E. and Koca, M. (2020) ‘Tyrosinase, cholinesterase inhibitory activity and molecular docking studies on apigenin and vitexin’, İstanbul Journal of Pharmacy, 50(3), pp. 268-271. https://doi.org/10.26650/IstanbulJPharm.2019.0076 (25 Apr. 2025).


MLA

Sezen Karaoğlan, Esen, and Mehmet Koca. “Tyrosinase, cholinesterase inhibitory activity and molecular docking studies on apigenin and vitexin.” İstanbul Journal of Pharmacy, vol. 50, no. 3, 2020, pp. 268-271. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2019.0076


Vancouver

Sezen Karaoğlan E, Koca M. Tyrosinase, cholinesterase inhibitory activity and molecular docking studies on apigenin and vitexin. İstanbul Journal of Pharmacy [Internet]. 25 Apr. 2025 [cited 25 Apr. 2025];50(3):268-271. Available from: https://doi.org/10.26650/IstanbulJPharm.2019.0076 doi: 10.26650/IstanbulJPharm.2019.0076


ISNAD

Sezen Karaoğlan, Esen - Koca, Mehmet. “Tyrosinase, cholinesterase inhibitory activity and molecular docking studies on apigenin and vitexin”. İstanbul Journal of Pharmacy 50/3 (Apr. 2025): 268-271. https://doi.org/10.26650/IstanbulJPharm.2019.0076



ZAMAN ÇİZELGESİ


Gönderim16.01.2020
Kabul29.06.2020
Çevrimiçi Yayınlanma13.11.2020

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