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DOI :10.26650/JARHS2020-S1-0012   IUP :10.26650/JARHS2020-S1-0012    Tam Metin (PDF)

Psikiyatrik Belirtilerin Olası Psikoimmünolojik Nedenleri Olarak Geçmişten Günümüze Viral Pandemiler

Hasan Mervan Aytaç, Sacide Pehlivan

İnsanlık tarihi geçmişten günümüze çok çeşitli viral salgınlara tanık olmuş, bu salgınların ardından, etkilenen toplumlarda nöropsikiyatrik, nörodejeneratif, nörodavranışsal ve otoimmün bozuklukların görülme sıklığında artış meydana gelmiştir. 19. ve 20. yüzyıllarda viral pandemilerin ardından psikotik bozukluk, kaygı bozukluğu, depresyon, mani ve intihar olgularında görülen dramatik artışlar büyük tartışmalara yol açmıştır. Psikiyatrik bozukluklarda görülen bu artışın viral salgınlara hazırlıksız yakalanan toplumların yaşadığı panik ve bunun neden olduğu travma ile açıklanmaya çalışılması altta yatan enfeksiyöz ajanları ve konakçıda tetikledikleri inflamasyonu ele almadan eksik kalacaktır. Son dönemde yapılan çalışmalar, viral enfeksiyonların ve tetikledikleri enflamatuvar mekanizmaların mikroglialarda kontrolsüz aktivitelere ve nörotransmitter fonksiyonlarında bozulmalara neden olduğu, bu durumun da genetik yatkınlık zemininde birçok psikiyatrik bozukluğa yol açtığını göstermektedir.Bu derlemede, SARS-CoV-2’nin (COVID-19 etmeni) neden olduğu düşünülen psikiyatrik bulgularla ilgili literatürde yer alan vaka sunumları ve klinik çalışmaları, altta yatan etiyolojik mekanizmaları ve sebep olduğu akut tabloların ileri dönemdeki olası psikoimmünolojik yansımalarını, geçmiş viral salgınları da göz önünde bulundurarak tartıştık.

Anahtar Kelimeler: COVID-19, SARS-CoV-2, pandemi, inflamasyon, psikiyatrik belirti
DOI :10.26650/JARHS2020-S1-0012   IUP :10.26650/JARHS2020-S1-0012    Tam Metin (PDF)

Viral Pandemics as Possible Psycho-immunological Causes of Psychiatric Symptoms: From Past to Present

Hasan Mervan Aytaç, Sacide Pehlivan

Human history has witnessed a wide variety of viral outbreaks from past to present, following these outbreaks, there has been an increase in the frequency of neuropsychiatric, neurodegenerative, neurobehavioral, and autoimmune disorders. Dramatic increases in psychotic disorder, anxiety disorder, depression, mania, and suicide cases after viral pandemics in the 19th and 20th centuries caused great debate. Trying to explain this increase in psychiatric disorders only with panic and trauma experienced by the populations who are caught unprepared for viral outbreaks will be incomplete without addressing the underlying infectious agents and the inflammation triggered in the host. Recent studies show that viral infections and inflammatory mechanisms triggered by them cause uncontrolled activities in microglia and impaired neurotransmitter functions, which leads to many psychiatric disorders based on genetic predisposition. In this review, we discusscase presentations and clinical studies in the literature related to acute psychiatric findings, which are thought to be associated with SARS-CoV-2(the virus that causes COVID-19), the underlying etiological mechanisms, and possible psychoimmunological reflections of these acute symptoms, by considering past viral outbreaks.

Anahtar Kelimeler: COVID-19, SARS-CoV-2, pandemic, inflammation, psychiatric symptom

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APA

Aytaç, H.M., & Pehlivan, S. (2020). Psikiyatrik Belirtilerin Olası Psikoimmünolojik Nedenleri Olarak Geçmişten Günümüze Viral Pandemiler. Sağlık Bilimlerinde İleri Araştırmalar Dergisi, 3(1), 92-98. https://doi.org/10.26650/JARHS2020-S1-0012


AMA

Aytaç H M, Pehlivan S. Psikiyatrik Belirtilerin Olası Psikoimmünolojik Nedenleri Olarak Geçmişten Günümüze Viral Pandemiler. Sağlık Bilimlerinde İleri Araştırmalar Dergisi. 2020;3(1):92-98. https://doi.org/10.26650/JARHS2020-S1-0012


ABNT

Aytaç, H.M.; Pehlivan, S. Psikiyatrik Belirtilerin Olası Psikoimmünolojik Nedenleri Olarak Geçmişten Günümüze Viral Pandemiler. Sağlık Bilimlerinde İleri Araştırmalar Dergisi, [Publisher Location], v. 3, n. 1, p. 92-98, 2020.


Chicago: Author-Date Style

Aytaç, Hasan Mervan, and Sacide Pehlivan. 2020. “Psikiyatrik Belirtilerin Olası Psikoimmünolojik Nedenleri Olarak Geçmişten Günümüze Viral Pandemiler.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi 3, no. 1: 92-98. https://doi.org/10.26650/JARHS2020-S1-0012


Chicago: Humanities Style

Aytaç, Hasan Mervan, and Sacide Pehlivan. “Psikiyatrik Belirtilerin Olası Psikoimmünolojik Nedenleri Olarak Geçmişten Günümüze Viral Pandemiler.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi 3, no. 1 (Apr. 2024): 92-98. https://doi.org/10.26650/JARHS2020-S1-0012


Harvard: Australian Style

Aytaç, HM & Pehlivan, S 2020, 'Psikiyatrik Belirtilerin Olası Psikoimmünolojik Nedenleri Olarak Geçmişten Günümüze Viral Pandemiler', Sağlık Bilimlerinde İleri Araştırmalar Dergisi, vol. 3, no. 1, pp. 92-98, viewed 27 Apr. 2024, https://doi.org/10.26650/JARHS2020-S1-0012


Harvard: Author-Date Style

Aytaç, H.M. and Pehlivan, S. (2020) ‘Psikiyatrik Belirtilerin Olası Psikoimmünolojik Nedenleri Olarak Geçmişten Günümüze Viral Pandemiler’, Sağlık Bilimlerinde İleri Araştırmalar Dergisi, 3(1), pp. 92-98. https://doi.org/10.26650/JARHS2020-S1-0012 (27 Apr. 2024).


MLA

Aytaç, Hasan Mervan, and Sacide Pehlivan. “Psikiyatrik Belirtilerin Olası Psikoimmünolojik Nedenleri Olarak Geçmişten Günümüze Viral Pandemiler.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi, vol. 3, no. 1, 2020, pp. 92-98. [Database Container], https://doi.org/10.26650/JARHS2020-S1-0012


Vancouver

Aytaç HM, Pehlivan S. Psikiyatrik Belirtilerin Olası Psikoimmünolojik Nedenleri Olarak Geçmişten Günümüze Viral Pandemiler. Sağlık Bilimlerinde İleri Araştırmalar Dergisi [Internet]. 27 Apr. 2024 [cited 27 Apr. 2024];3(1):92-98. Available from: https://doi.org/10.26650/JARHS2020-S1-0012 doi: 10.26650/JARHS2020-S1-0012


ISNAD

Aytaç, HasanMervan - Pehlivan, Sacide. “Psikiyatrik Belirtilerin Olası Psikoimmünolojik Nedenleri Olarak Geçmişten Günümüze Viral Pandemiler”. Sağlık Bilimlerinde İleri Araştırmalar Dergisi 3/1 (Apr. 2024): 92-98. https://doi.org/10.26650/JARHS2020-S1-0012



ZAMAN ÇİZELGESİ


Gönderim24.04.2020
Kabul03.05.2020
Çevrimiçi Yayınlanma15.05.2020

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