References

• 1. Chanchal DK, Alok S, Rashi S, Bijauliya RK, Yadav RD, Sabharwal M. Various medicinal plants used in the treatment of anticancer activity. Int J Pharm Sci Res 2018; 9(4): 1424-9. google scholar
• 2. Ohiagu FO, Chikezie PC, Chikezie CM, Enyoh CE. Anticancer activity of Nigerian medicinal plants: a review. Futur J Pharm Sci 2021; 7: 70. google scholar
• 3. Khalil MIM, Ibrahim MM, El-Gaaly GA, Sultan AS. Trigonella foenum(Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 and Proliferating Cell Nuclear Antigen. BioMed Res Int 2015; 2015: 914645. google scholar
• 4. Al-Oqail MM, Farshori NN, Al-Sheddi ES, Musarrat J, Al-Khedhairy AA, Siddiqui MA. In vitro cytotoxic activity of seed oil of fenugreek against various cancer cell lines. Asian Pac J Cancer Prev 2013; 14(3): 1829-32. google scholar
• 5. Marshall GM, Carter DR, Cheung BB, Liu T, Mateos MK, Meyerowitz JG et al. The prenatal origins of cancer. Nat Rev Cancer 2014; 14(4): 277-89. google scholar
• 6. Li J, Pang J, Liu Y, Zhang J, Zhang C, Shen G et al. Suppression of RRM2 inhibits cell proliferation, causes cell cycle arrest and promotes the apoptosis of human neuroblastoma cells and in human neuroblastoma RRM2 is suppressed following chemotherapy. Oncol rep 2018; 40(1): 355-60. google scholar
• 7. Cortelo PC, Demarque DP, Dusi RG, Albernaz LC, Braz-Filho R, Goncharova EI et al. A Molecular Networking Strategy: High-Throughput Screening and Chemical Analysis of Brazilian Cerrado Plant Extracts against Cancer Cells. Cells 2021; 10(3): 691. google scholar
• 8. Aydemir EA, Simsek E, Imir N, Göktürk RS, Yesilada E, Fiskin K. Cytotoxic and apoptotic effects of Ebenus boissieri Barbey on human lung cancer cell line A549. Pharmacogn Mag 2015; 11(42): 37-45. google scholar
• 9. Khoja KK, Howes MJR, Hider R, Sharp PA, Farrell IW, Latunde-Dada GO. Cytotoxicity of Fenugreek Sprout and Seed Extracts and Their Bioactive Constituents on MCF-7 Breast Cancer Cells. Nutrients 2022; 14(4): 784. google scholar
• 10. Wani SA, Kumar P. Fenugreek: A review on its nutraceutical properties and utilization in various food products. J Saudi Soc Agric Sci 2018; 17(2), 97-106. google scholar
• 11. Rahmati-Yamchi M, Ghareghomi S, Haddadchi G, Milani M, Aghaz-ade M, Daroushnejad H. Fenugreek extract diosgenin and pure diosgenin inhibit the hTERT gene expression in A549 lung cancer cell line. Mol Biol 2014; 41: 6247-52. google scholar
• 12. Zameer S, Najmi AK, Vohora D, Akhtar M. A review on therapeutic potentials of Trigonella foenum graecum (fenugreek) and its chemical constituents in neurological disorders: Complementary roles to its hypolipidemic, hypoglycemic, and antioxidant potential. Nutr Neurosci 2018; 21(8): 539-45. google scholar
• 13. Sebastian KS, Thampan RV. Differential effects of soybean and fenugreek extracts on the growth of MCF-7 cells. Chem Biol Interact 2007; 170(2): 135-43. google scholar
• 14. Khoja KK, Howes MJR, Hider R, Sharp PA, Farrell IW, Latunde-Dada GO. Cytotoxicity of Fenugreek Sprout and Seed Extracts and Their Bioactive Constituents on MCF-7 Breast Cancer Cells. Nutrients 2022; 14(4): 784. google scholar
• 15. Khoja KK, Shaf G, Hasan TN, Syed NA, Al-Khalifa AS, Al-Assaf AH, Alshatwi AA. Fenugreek, a naturally occurring edible spice, kills MCF-7 human breast cancer cells via an apoptotic pathway. Asian Pac J Cancer Prev 2011; 12(12): 3299-304. google scholar
• 16. Kaviarasan S, Ramamurty N, Gunasekaran P, Varalakshmi E, Anuradha CV. Fenugreek (Trigonella foenum graecum) seed extract prevents ethanol-induced toxicity and apoptosis in chang liver cells. Alcohol & Alcoholism 2006; 41(3): 267-73. google scholar
• 17. Syed QA, Rashid Z, Ahmad MH, Shukat R, Ishaq A, Muhammad N, et al. Nutritional and therapeutic properties of fenugreek (Trigonella foenum-graecum): a review. Int J Food Prop 2020; 23: 1777-91. google scholar
• 18. Verma KS, Singh KS, Mathur A. In vitro cytotoxicity of Calotropis procera and Trigonella foenumgraecum against human cancer cell lines. J Chem Pharm Res 2010; 2(4): 861-5. google scholar
• 19. Nelson VK, Sahoo NK, Sahu M, Sudhan HH, Pullaiah CP, Muralikrish-na KS. In vitro anticancer activity of Eclipta alba whole plant extract on colon cancer cell HCT-116. BMC Complement Med Ther 2020; 20(1): 355. google scholar
• 20. Alrumaihi FA, Khan MA, Allemailem KS, Alsahli MA, Almatroudi A, Younus H, et al. Methanolic fenugreek seed extract induces p53-dependent mitotic catastrophe in breast cancer cells, leading to apoptosis. J Inflamm Res 2021; 16(14): 1511-35. google scholar
• 21. Sitarek P, Kowalczyk T, Santangelo S, Bialas JA, Toma M, Wieczfins-ka J. The Extract of Leonurus sibiricus transgenic roots with AtPAP1 transcriptional factor induces apoptosis via DNA damage and down regulation of selected epigenetic factors in human cancer cells. Neurochem Res 2018; 43: 1363-70. google scholar
• 22. Alshatwi AA, Shafi G, Hasan TN, Syed NA, Khoja KK. Fenugreek induced apoptosis in breast cancer MCF-7 cells mediated independently by fas receptor change. Asian Pac J Cancer Prev 2013; 14(10): 5783-8. google scholar

Citations