Research Article


DOI :10.26650/EurJBiol.2023.1307239   IUP :10.26650/EurJBiol.2023.1307239    Full Text (PDF)

Effect of Gluten-Free Diet on Serum Antioxidant Levels in Children with Celiac

Mehmet Ali GülFatma Betül ÖzgerişNezahat KurtBurcu VolkanAli İşlekAtilla Çayır

Objective: Celiac disease (CD) is an inflammatory condition of the small intestine triggered by the consumption of gluten. A strict gluten-free diet (GFD) is the only treatment that can eliminate CD complications. It was aimed to evaluate the effect of a gluten-free diet on serum total glutathione (tGSH) level, superoxide dismutase (SOD), myeloperoxida (MPO), paroxanase (PON-1) and aryl esterase (ARE) activity in patients with celiac disease, an autoimmune disease.

Materials and Methods: The study was conducted with 68 participants, 39 of whom were celiac and 29 were healthy. Two groups were formed in patients with celiac disease as newly diagnosed and previously diagnosed and following a gluten-free diet. Blood samples were taken from all participants and tGSH, SOD, MPO, PON-1, and ARE measurements were made spectrophotometrically from serum samples.

Results: While no significant change was observed in tGSH, SOD, and ARE levels, MPO activity was observed to be significantly lower in celiac patients compared to healthy controls, while this decrease was found to be higher in the newly diagnosed group. While PON-1 activity was significantly lower in newly diagnosed patients compared to the control group, it was higher in the gluten-compatible diet group.

Conclusion: Low MPO values in celiac patients may be insufficient to function by creating oxidative stress in inflammation. While PON-1 values are significantly lower in newly diagnosed celiacs, it can be said that they reach normal values with adherence to a gluten-free diet.


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APA

Gül, M.A., Özgeriş, F.B., Kurt, N., Volkan, B., İşlek, A., & Çayır, A. (2023). Effect of Gluten-Free Diet on Serum Antioxidant Levels in Children with Celiac. European Journal of Biology, 82(2), 263-269. https://doi.org/10.26650/EurJBiol.2023.1307239


AMA

Gül M A, Özgeriş F B, Kurt N, Volkan B, İşlek A, Çayır A. Effect of Gluten-Free Diet on Serum Antioxidant Levels in Children with Celiac. European Journal of Biology. 2023;82(2):263-269. https://doi.org/10.26650/EurJBiol.2023.1307239


ABNT

Gül, M.A.; Özgeriş, F.B.; Kurt, N.; Volkan, B.; İşlek, A.; Çayır, A. Effect of Gluten-Free Diet on Serum Antioxidant Levels in Children with Celiac. European Journal of Biology, [Publisher Location], v. 82, n. 2, p. 263-269, 2023.


Chicago: Author-Date Style

Gül, Mehmet Ali, and Fatma Betül Özgeriş and Nezahat Kurt and Burcu Volkan and Ali İşlek and Atilla Çayır. 2023. “Effect of Gluten-Free Diet on Serum Antioxidant Levels in Children with Celiac.” European Journal of Biology 82, no. 2: 263-269. https://doi.org/10.26650/EurJBiol.2023.1307239


Chicago: Humanities Style

Gül, Mehmet Ali, and Fatma Betül Özgeriş and Nezahat Kurt and Burcu Volkan and Ali İşlek and Atilla Çayır. Effect of Gluten-Free Diet on Serum Antioxidant Levels in Children with Celiac.” European Journal of Biology 82, no. 2 (Mar. 2024): 263-269. https://doi.org/10.26650/EurJBiol.2023.1307239


Harvard: Australian Style

Gül, MA & Özgeriş, FB & Kurt, N & Volkan, B & İşlek, A & Çayır, A 2023, 'Effect of Gluten-Free Diet on Serum Antioxidant Levels in Children with Celiac', European Journal of Biology, vol. 82, no. 2, pp. 263-269, viewed 3 Mar. 2024, https://doi.org/10.26650/EurJBiol.2023.1307239


Harvard: Author-Date Style

Gül, M.A. and Özgeriş, F.B. and Kurt, N. and Volkan, B. and İşlek, A. and Çayır, A. (2023) ‘Effect of Gluten-Free Diet on Serum Antioxidant Levels in Children with Celiac’, European Journal of Biology, 82(2), pp. 263-269. https://doi.org/10.26650/EurJBiol.2023.1307239 (3 Mar. 2024).


MLA

Gül, Mehmet Ali, and Fatma Betül Özgeriş and Nezahat Kurt and Burcu Volkan and Ali İşlek and Atilla Çayır. Effect of Gluten-Free Diet on Serum Antioxidant Levels in Children with Celiac.” European Journal of Biology, vol. 82, no. 2, 2023, pp. 263-269. [Database Container], https://doi.org/10.26650/EurJBiol.2023.1307239


Vancouver

Gül MA, Özgeriş FB, Kurt N, Volkan B, İşlek A, Çayır A. Effect of Gluten-Free Diet on Serum Antioxidant Levels in Children with Celiac. European Journal of Biology [Internet]. 3 Mar. 2024 [cited 3 Mar. 2024];82(2):263-269. Available from: https://doi.org/10.26650/EurJBiol.2023.1307239 doi: 10.26650/EurJBiol.2023.1307239


ISNAD

Gül, MehmetAli - Özgeriş, FatmaBetül - Kurt, Nezahat - Volkan, Burcu - İşlek, Ali - Çayır, Atilla. Effect of Gluten-Free Diet on Serum Antioxidant Levels in Children with Celiac”. European Journal of Biology 82/2 (Mar. 2024): 263-269. https://doi.org/10.26650/EurJBiol.2023.1307239



TIMELINE


Submitted08.06.2023
Accepted09.07.2023
Published Online13.10.2023

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