Research Article


DOI :10.26650/EurJBiol.2019.0034   IUP :10.26650/EurJBiol.2019.0034    Full Text (PDF)

Effects of Tempol in Lipopolysaccharide-Induced Liver Injury

Perihan Sinem SerinAslı KandilHuri BulutTuğba KaskavalcıErman Caner BulutCihan Demirci Tansel

Objective: Sepsis leads to conditions such as inflammatory and anti-inflammatory process, circulatory abnormalities, cellular and humoral reactions. Endotoxin-induced oxidative stress causes injury in the liver. The aim of this study was to evaluate the effects of a radical scavenger Tempol in lipopolysaccharide (LPS)-induced liver injury in rats. Materials and Methods: Male Wistar rats were divided into four groups: Control, LPS (15 mg/kg), LPS + Tempol group (100 mg/kg Tempol, three hours after LPS administration) and Tempol (100 mg/kg). Blood glucose and body temperature were measured during the experiment. Superoxide dismutase (SOD), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and C-reactive protein (CRP) levels were measured in plasma or liver tissue. Furthermore, histopathological changes and myeloperoxidase-stained leukocytes infiltration were assessed in liver tissue. Results: LPS caused tissue damage and leukocytes infiltration, increased AST, ALT and CRP levels, and decreased body temperature, blood glucose and SOD levels. Tempol reduced AST and ALT levels and increased SOD levels. Tempol did not prevent tissue damage, leukocytes infiltration and increment of CRP levels. There were no changes in body temperature and blood glucose levels. Conclusion: The present study suggests that tempol may have antioxidant properties in LPS-induced liver injury. These results may contribute to a better understanding of the role of tempol and basic mechanisms of underlying oxidative stressrelated liver injury for further investigations.

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APA

Serin, P.S., Kandil, A., Bulut, H., Kaskavalcı, T., Bulut, E.C., & Demirci Tansel, C. (2019). Effects of Tempol in Lipopolysaccharide-Induced Liver Injury. European Journal of Biology, 78(2), 147-155. https://doi.org/10.26650/EurJBiol.2019.0034


AMA

Serin P S, Kandil A, Bulut H, Kaskavalcı T, Bulut E C, Demirci Tansel C. Effects of Tempol in Lipopolysaccharide-Induced Liver Injury. European Journal of Biology. 2019;78(2):147-155. https://doi.org/10.26650/EurJBiol.2019.0034


ABNT

Serin, P.S.; Kandil, A.; Bulut, H.; Kaskavalcı, T.; Bulut, E.C.; Demirci Tansel, C. Effects of Tempol in Lipopolysaccharide-Induced Liver Injury. European Journal of Biology, [Publisher Location], v. 78, n. 2, p. 147-155, 2019.


Chicago: Author-Date Style

Serin, Perihan Sinem, and Aslı Kandil and Huri Bulut and Tuğba Kaskavalcı and Erman Caner Bulut and Cihan Demirci Tansel. 2019. “Effects of Tempol in Lipopolysaccharide-Induced Liver Injury.” European Journal of Biology 78, no. 2: 147-155. https://doi.org/10.26650/EurJBiol.2019.0034


Chicago: Humanities Style

Serin, Perihan Sinem, and Aslı Kandil and Huri Bulut and Tuğba Kaskavalcı and Erman Caner Bulut and Cihan Demirci Tansel. Effects of Tempol in Lipopolysaccharide-Induced Liver Injury.” European Journal of Biology 78, no. 2 (Dec. 2024): 147-155. https://doi.org/10.26650/EurJBiol.2019.0034


Harvard: Australian Style

Serin, PS & Kandil, A & Bulut, H & Kaskavalcı, T & Bulut, EC & Demirci Tansel, C 2019, 'Effects of Tempol in Lipopolysaccharide-Induced Liver Injury', European Journal of Biology, vol. 78, no. 2, pp. 147-155, viewed 23 Dec. 2024, https://doi.org/10.26650/EurJBiol.2019.0034


Harvard: Author-Date Style

Serin, P.S. and Kandil, A. and Bulut, H. and Kaskavalcı, T. and Bulut, E.C. and Demirci Tansel, C. (2019) ‘Effects of Tempol in Lipopolysaccharide-Induced Liver Injury’, European Journal of Biology, 78(2), pp. 147-155. https://doi.org/10.26650/EurJBiol.2019.0034 (23 Dec. 2024).


MLA

Serin, Perihan Sinem, and Aslı Kandil and Huri Bulut and Tuğba Kaskavalcı and Erman Caner Bulut and Cihan Demirci Tansel. Effects of Tempol in Lipopolysaccharide-Induced Liver Injury.” European Journal of Biology, vol. 78, no. 2, 2019, pp. 147-155. [Database Container], https://doi.org/10.26650/EurJBiol.2019.0034


Vancouver

Serin PS, Kandil A, Bulut H, Kaskavalcı T, Bulut EC, Demirci Tansel C. Effects of Tempol in Lipopolysaccharide-Induced Liver Injury. European Journal of Biology [Internet]. 23 Dec. 2024 [cited 23 Dec. 2024];78(2):147-155. Available from: https://doi.org/10.26650/EurJBiol.2019.0034 doi: 10.26650/EurJBiol.2019.0034


ISNAD

Serin, PerihanSinem - Kandil, Aslı - Bulut, Huri - Kaskavalcı, Tuğba - Bulut, ErmanCaner - Demirci Tansel, Cihan. Effects of Tempol in Lipopolysaccharide-Induced Liver Injury”. European Journal of Biology 78/2 (Dec. 2024): 147-155. https://doi.org/10.26650/EurJBiol.2019.0034



TIMELINE


Submitted20.09.2019
Accepted29.11.2019
Published Online06.12.2019

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