Research Article


DOI :10.26650/EurJBiol.2025.1601900   IUP :10.26650/EurJBiol.2025.1601900    Full Text (PDF)

Identification of New Variants Related to Epilepsy in the Reanalysis of NGS Data of Patients with Epilepsy and Intellectual Disorders

Kawes Omer ZanganaNaser GilaniMassoud Houshmand

Objective: Epilepsy is a chronic, noncommunicable brain disorder affecting individuals of all ages, with over 50 million cases worldwide. Advances in next-generation sequencing have enabled the identification of disease-related gene mutations; however, the yield of whole-exome sequencing (WES) for patients with epilepsy remains variable. Given our limited knowledge and the continual updates in genetic databases, reanalysis of older sequencing results may reveal relevant mutations and uncover false negatives.

Materials and Methods: In this study, we reanalyzed the initial WES data and clinical information for 12 patients with previously negative results.

Results: New mutations were identified in 5 patients and associated with 5 genes.

Conclusion: Thus, for patients with a strong suspicion of genetic disease, re-evaluating WES data is recommended even if the initial findings are negative.


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APA

Zangana, K.O., Gilani, N., & Houshmand, M. (2025). Identification of New Variants Related to Epilepsy in the Reanalysis of NGS Data of Patients with Epilepsy and Intellectual Disorders. European Journal of Biology, 84(1), 114-120. https://doi.org/10.26650/EurJBiol.2025.1601900


AMA

Zangana K O, Gilani N, Houshmand M. Identification of New Variants Related to Epilepsy in the Reanalysis of NGS Data of Patients with Epilepsy and Intellectual Disorders. European Journal of Biology. 2025;84(1):114-120. https://doi.org/10.26650/EurJBiol.2025.1601900


ABNT

Zangana, K.O.; Gilani, N.; Houshmand, M. Identification of New Variants Related to Epilepsy in the Reanalysis of NGS Data of Patients with Epilepsy and Intellectual Disorders. European Journal of Biology, [Publisher Location], v. 84, n. 1, p. 114-120, 2025.


Chicago: Author-Date Style

Zangana, Kawes Omer, and Naser Gilani and Massoud Houshmand. 2025. “Identification of New Variants Related to Epilepsy in the Reanalysis of NGS Data of Patients with Epilepsy and Intellectual Disorders.” European Journal of Biology 84, no. 1: 114-120. https://doi.org/10.26650/EurJBiol.2025.1601900


Chicago: Humanities Style

Zangana, Kawes Omer, and Naser Gilani and Massoud Houshmand. Identification of New Variants Related to Epilepsy in the Reanalysis of NGS Data of Patients with Epilepsy and Intellectual Disorders.” European Journal of Biology 84, no. 1 (Sep. 2025): 114-120. https://doi.org/10.26650/EurJBiol.2025.1601900


Harvard: Australian Style

Zangana, KO & Gilani, N & Houshmand, M 2025, 'Identification of New Variants Related to Epilepsy in the Reanalysis of NGS Data of Patients with Epilepsy and Intellectual Disorders', European Journal of Biology, vol. 84, no. 1, pp. 114-120, viewed 20 Sep. 2025, https://doi.org/10.26650/EurJBiol.2025.1601900


Harvard: Author-Date Style

Zangana, K.O. and Gilani, N. and Houshmand, M. (2025) ‘Identification of New Variants Related to Epilepsy in the Reanalysis of NGS Data of Patients with Epilepsy and Intellectual Disorders’, European Journal of Biology, 84(1), pp. 114-120. https://doi.org/10.26650/EurJBiol.2025.1601900 (20 Sep. 2025).


MLA

Zangana, Kawes Omer, and Naser Gilani and Massoud Houshmand. Identification of New Variants Related to Epilepsy in the Reanalysis of NGS Data of Patients with Epilepsy and Intellectual Disorders.” European Journal of Biology, vol. 84, no. 1, 2025, pp. 114-120. [Database Container], https://doi.org/10.26650/EurJBiol.2025.1601900


Vancouver

Zangana KO, Gilani N, Houshmand M. Identification of New Variants Related to Epilepsy in the Reanalysis of NGS Data of Patients with Epilepsy and Intellectual Disorders. European Journal of Biology [Internet]. 20 Sep. 2025 [cited 20 Sep. 2025];84(1):114-120. Available from: https://doi.org/10.26650/EurJBiol.2025.1601900 doi: 10.26650/EurJBiol.2025.1601900


ISNAD

Zangana, KawesOmer - Gilani, Naser - Houshmand, Massoud. Identification of New Variants Related to Epilepsy in the Reanalysis of NGS Data of Patients with Epilepsy and Intellectual Disorders”. European Journal of Biology 84/1 (Sep. 2025): 114-120. https://doi.org/10.26650/EurJBiol.2025.1601900



TIMELINE


Submitted15.12.2024
Accepted02.05.2025
Published Online05.06.2025

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