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DOI :10.26650/EurJBiol.2024.1399845   IUP :10.26650/EurJBiol.2024.1399845    Full Text (PDF)

Induction of Apoptosis in BCR-ABL Fusion Associated Chronic Myeloid Leukemia Cells by Camellia kissiWall. (Theaceae) Extract

Nguyen Anh XuanNguyen Trung QuanBui Thi Kim LyHoang Thanh Chi

Objective: Camellia kissi, a prominent tea, lacks academic works. In a previous report, this plant substantially affected chronic myeloid leukemia cells. Understanding the mechanism of action of this tea species on leukemia cells will contribute to researching alternative treatment methods in the context of drug resistance in chronic myeloid leukemia, which is constantly increasing.

Materials and Methods: C. kissi comes from Lam Dong, Vietnam. The crude tea extract in methanol was obtained. The flow cytometry method with Annexin V and PI staining and the DNA fragmentation assays were used to indicate the apoptosis cells. The reversed transcription real-time PCR reactions were conducted to measure the mRNA level under the treatment.

Results: The results showed the apoptosis-inducing capacity of the C. kissi extract on K562 cells, and the impact was suggested to be through the induction of intracellular apoptosis and cell cycle arrest.

Conclusion: The apoptosis induction on K562 caused by C. kissi was reported for the first time. Initial recognition of the signaling pathway of inhibition is through the BCR-ABL/PTEN. 


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APA

Xuan, N.A., Quan, N.T., Ly, B.T., & Chi, H.T. (2024). Induction of Apoptosis in BCR-ABL Fusion Associated Chronic Myeloid Leukemia Cells by Camellia kissiWall. (Theaceae) Extract. European Journal of Biology, 83(1), 117-122. https://doi.org/10.26650/EurJBiol.2024.1399845


AMA

Xuan N A, Quan N T, Ly B T, Chi H T. Induction of Apoptosis in BCR-ABL Fusion Associated Chronic Myeloid Leukemia Cells by Camellia kissiWall. (Theaceae) Extract. European Journal of Biology. 2024;83(1):117-122. https://doi.org/10.26650/EurJBiol.2024.1399845


ABNT

Xuan, N.A.; Quan, N.T.; Ly, B.T.; Chi, H.T. Induction of Apoptosis in BCR-ABL Fusion Associated Chronic Myeloid Leukemia Cells by Camellia kissiWall. (Theaceae) Extract. European Journal of Biology, [Publisher Location], v. 83, n. 1, p. 117-122, 2024.


Chicago: Author-Date Style

Xuan, Nguyen Anh, and Nguyen Trung Quan and Bui Thi Kim Ly and Hoang Thanh Chi. 2024. “Induction of Apoptosis in BCR-ABL Fusion Associated Chronic Myeloid Leukemia Cells by Camellia kissiWall. (Theaceae) Extract.” European Journal of Biology 83, no. 1: 117-122. https://doi.org/10.26650/EurJBiol.2024.1399845


Chicago: Humanities Style

Xuan, Nguyen Anh, and Nguyen Trung Quan and Bui Thi Kim Ly and Hoang Thanh Chi. Induction of Apoptosis in BCR-ABL Fusion Associated Chronic Myeloid Leukemia Cells by Camellia kissiWall. (Theaceae) Extract.” European Journal of Biology 83, no. 1 (Nov. 2024): 117-122. https://doi.org/10.26650/EurJBiol.2024.1399845


Harvard: Australian Style

Xuan, NA & Quan, NT & Ly, BT & Chi, HT 2024, 'Induction of Apoptosis in BCR-ABL Fusion Associated Chronic Myeloid Leukemia Cells by Camellia kissiWall. (Theaceae) Extract', European Journal of Biology, vol. 83, no. 1, pp. 117-122, viewed 22 Nov. 2024, https://doi.org/10.26650/EurJBiol.2024.1399845


Harvard: Author-Date Style

Xuan, N.A. and Quan, N.T. and Ly, B.T. and Chi, H.T. (2024) ‘Induction of Apoptosis in BCR-ABL Fusion Associated Chronic Myeloid Leukemia Cells by Camellia kissiWall. (Theaceae) Extract’, European Journal of Biology, 83(1), pp. 117-122. https://doi.org/10.26650/EurJBiol.2024.1399845 (22 Nov. 2024).


MLA

Xuan, Nguyen Anh, and Nguyen Trung Quan and Bui Thi Kim Ly and Hoang Thanh Chi. Induction of Apoptosis in BCR-ABL Fusion Associated Chronic Myeloid Leukemia Cells by Camellia kissiWall. (Theaceae) Extract.” European Journal of Biology, vol. 83, no. 1, 2024, pp. 117-122. [Database Container], https://doi.org/10.26650/EurJBiol.2024.1399845


Vancouver

Xuan NA, Quan NT, Ly BT, Chi HT. Induction of Apoptosis in BCR-ABL Fusion Associated Chronic Myeloid Leukemia Cells by Camellia kissiWall. (Theaceae) Extract. European Journal of Biology [Internet]. 22 Nov. 2024 [cited 22 Nov. 2024];83(1):117-122. Available from: https://doi.org/10.26650/EurJBiol.2024.1399845 doi: 10.26650/EurJBiol.2024.1399845


ISNAD

Xuan, NguyenAnh - Quan, NguyenTrung - Ly, BuiThi Kim - Chi, HoangThanh. Induction of Apoptosis in BCR-ABL Fusion Associated Chronic Myeloid Leukemia Cells by Camellia kissiWall. (Theaceae) Extract”. European Journal of Biology 83/1 (Nov. 2024): 117-122. https://doi.org/10.26650/EurJBiol.2024.1399845



TIMELINE


Submitted04.12.2023
Accepted19.01.2024
Published Online23.02.2024

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