Research Article


DOI :10.26650/EurJBiol.2022.1097938   IUP :10.26650/EurJBiol.2022.1097938    Full Text (PDF)

Inflammation Parameters, Xanthine Oxidase and Anti-Xanthine Oxidase Antibodies in Synovial Fluid of Patients Suffering from Arthritis

Nadjet HanachiLekhmici Arrar

Objective: Rheumatoid arthritis (RA) is an autoimmune disease where sera and synovial fluid (SF) of suffering patients contain immune complexes formed from autoantibodies to several proteins. SF from humans with joint diseases was examined for the presence of some inflammatory parameters and autoantibodies. Materials and Methods: Antibodies in their free and complex forms were assayed by indirect ELISA. The immunoprecipitation technique was used to evaluate total IgG and IgM and complement. Results: The results showed that most RA SF was anti-ASLO negative, but they were CRP positive. Levels of complement components (C3 and C4) were highest in the group of mono-/oligo-arthritis and lowest in RA. The results showed that xanthine oxidase (XO) presence and activity were important in SF of RA patients. Moreover, free and complex anti-XO antibodies were detected in all SF with different titers throughout the groups of patients where IgG was lower than IgM. Conclusion: The studied parameters of inflammation and auto-antibodies especially against XO could serve as an evaluation of the severity of joint inflammation and in RA pathogenesis understanding.


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APA

Hanachi, N., & Arrar, L. (2022). Inflammation Parameters, Xanthine Oxidase and Anti-Xanthine Oxidase Antibodies in Synovial Fluid of Patients Suffering from Arthritis. European Journal of Biology, 81(2), 136-143. https://doi.org/10.26650/EurJBiol.2022.1097938


AMA

Hanachi N, Arrar L. Inflammation Parameters, Xanthine Oxidase and Anti-Xanthine Oxidase Antibodies in Synovial Fluid of Patients Suffering from Arthritis. European Journal of Biology. 2022;81(2):136-143. https://doi.org/10.26650/EurJBiol.2022.1097938


ABNT

Hanachi, N.; Arrar, L. Inflammation Parameters, Xanthine Oxidase and Anti-Xanthine Oxidase Antibodies in Synovial Fluid of Patients Suffering from Arthritis. European Journal of Biology, [Publisher Location], v. 81, n. 2, p. 136-143, 2022.


Chicago: Author-Date Style

Hanachi, Nadjet, and Lekhmici Arrar. 2022. “Inflammation Parameters, Xanthine Oxidase and Anti-Xanthine Oxidase Antibodies in Synovial Fluid of Patients Suffering from Arthritis.” European Journal of Biology 81, no. 2: 136-143. https://doi.org/10.26650/EurJBiol.2022.1097938


Chicago: Humanities Style

Hanachi, Nadjet, and Lekhmici Arrar. Inflammation Parameters, Xanthine Oxidase and Anti-Xanthine Oxidase Antibodies in Synovial Fluid of Patients Suffering from Arthritis.” European Journal of Biology 81, no. 2 (Apr. 2024): 136-143. https://doi.org/10.26650/EurJBiol.2022.1097938


Harvard: Australian Style

Hanachi, N & Arrar, L 2022, 'Inflammation Parameters, Xanthine Oxidase and Anti-Xanthine Oxidase Antibodies in Synovial Fluid of Patients Suffering from Arthritis', European Journal of Biology, vol. 81, no. 2, pp. 136-143, viewed 20 Apr. 2024, https://doi.org/10.26650/EurJBiol.2022.1097938


Harvard: Author-Date Style

Hanachi, N. and Arrar, L. (2022) ‘Inflammation Parameters, Xanthine Oxidase and Anti-Xanthine Oxidase Antibodies in Synovial Fluid of Patients Suffering from Arthritis’, European Journal of Biology, 81(2), pp. 136-143. https://doi.org/10.26650/EurJBiol.2022.1097938 (20 Apr. 2024).


MLA

Hanachi, Nadjet, and Lekhmici Arrar. Inflammation Parameters, Xanthine Oxidase and Anti-Xanthine Oxidase Antibodies in Synovial Fluid of Patients Suffering from Arthritis.” European Journal of Biology, vol. 81, no. 2, 2022, pp. 136-143. [Database Container], https://doi.org/10.26650/EurJBiol.2022.1097938


Vancouver

Hanachi N, Arrar L. Inflammation Parameters, Xanthine Oxidase and Anti-Xanthine Oxidase Antibodies in Synovial Fluid of Patients Suffering from Arthritis. European Journal of Biology [Internet]. 20 Apr. 2024 [cited 20 Apr. 2024];81(2):136-143. Available from: https://doi.org/10.26650/EurJBiol.2022.1097938 doi: 10.26650/EurJBiol.2022.1097938


ISNAD

Hanachi, Nadjet - Arrar, Lekhmici. Inflammation Parameters, Xanthine Oxidase and Anti-Xanthine Oxidase Antibodies in Synovial Fluid of Patients Suffering from Arthritis”. European Journal of Biology 81/2 (Apr. 2024): 136-143. https://doi.org/10.26650/EurJBiol.2022.1097938



TIMELINE


Submitted04.04.2022
Accepted04.10.2022
Published Online24.11.2022

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