European Journal of Biology

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Research Article


DOI :10.26650/EurJBiol.2019.0017   IUP :10.26650/EurJBiol.2019.0017    Full Text (PDF)

Investigation of Antimicrobial, Antibiofilm, and Cytotoxic Effects of Straight-Chained Sulfanyl Members of Arylamino-1,4-naphthoquinones as Potential Antimicrobial Agents

Emel Mataracı Kara, Ayşe Tarbın Jannuzzi, Nilüfer Bayrak, Hatice Yıldırım, Mahmut Yıldız, Amaç Fatih Tuyun, Buket Alpertunga, Berna Özbek Çelik

Objective: Naphthoquinone derivatives are known to have antibacterial activity and are likely to succeed a new class of compound that can be applied as antimicrobial agents.

Materials and Methods: The purpose of this experiment was to evaluate the potential antimicrobial, antibiofilm, anticancer, and cytotoxic activities of six naphthoquinone compounds previously reported in the literature.

Results: According to our studies, 2-(4-(trifluoromethyl)phenylamino)-3-(propylthio)naphthalene-1,4-dione (5a) and 2-(4-(trifluoromethyl)phenylamino)-3-(pentylthio)naphthalene-1,4-dione (5b) were found to have good antimicrobial activity against Staphylococcus aureus ATCC 29213 with 1.22 and 19.53 µg/mL MIC values, respectively. When we carried out the test against biofilm, the most effective agent, 5a, showed up to 40% inhibition of the S. aureus’s biofilm at the 1 x MIC concentration. However, when we investigated the cytotoxic effect of 5a on the cancer and non-cancer cell lines, we found that 5a showed higher toxicity to cancer cell lines.

Conclusion: The findings of our study suggest that further studies to develop these compounds and investigate its pharmacological properties could be useful to define the functionality of them as antimicrobial or anticancer agents.

Keywords: Sulfanyl 1, 4-naphthoquinone, Arylamine, Antimicrobial activity, Cytotoxicity, Biofilm

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APA

Mataracı Kara, E., Jannuzzi, A.T., Bayrak, N., Yıldırım, H., Yıldız, M., Tuyun, A.F., Alpertunga, B., & Özbek Çelik, B. (2019). Investigation of Antimicrobial, Antibiofilm, and Cytotoxic Effects of Straight-Chained Sulfanyl Members of Arylamino-1,4-naphthoquinones as Potential Antimicrobial Agents. European Journal of Biology, 78(2), 117-123. https://doi.org/10.26650/EurJBiol.2019.0017


AMA

Mataracı Kara E, Jannuzzi A T, Bayrak N, Yıldırım H, Yıldız M, Tuyun A F, Alpertunga B, Özbek Çelik B. Investigation of Antimicrobial, Antibiofilm, and Cytotoxic Effects of Straight-Chained Sulfanyl Members of Arylamino-1,4-naphthoquinones as Potential Antimicrobial Agents. European Journal of Biology. 2019;78(2):117-123. https://doi.org/10.26650/EurJBiol.2019.0017


ABNT

Mataracı Kara, E.; Jannuzzi, A.T.; Bayrak, N.; Yıldırım, H.; Yıldız, M.; Tuyun, A.F.; Alpertunga, B.; Özbek Çelik, B. Investigation of Antimicrobial, Antibiofilm, and Cytotoxic Effects of Straight-Chained Sulfanyl Members of Arylamino-1,4-naphthoquinones as Potential Antimicrobial Agents. European Journal of Biology, [Publisher Location], v. 78, n. 2, p. 117-123, 2019.


Chicago: Author-Date Style

Mataracı Kara, Emel, and Ayşe Tarbın Jannuzzi and Nilüfer Bayrak and Hatice Yıldırım and Mahmut Yıldız and Amaç Fatih Tuyun and Buket Alpertunga and Berna Özbek Çelik. 2019. “Investigation of Antimicrobial, Antibiofilm, and Cytotoxic Effects of Straight-Chained Sulfanyl Members of Arylamino-1,4-naphthoquinones as Potential Antimicrobial Agents.” European Journal of Biology 78, no. 2: 117-123. https://doi.org/10.26650/EurJBiol.2019.0017


Chicago: Humanities Style

Mataracı Kara, Emel, and Ayşe Tarbın Jannuzzi and Nilüfer Bayrak and Hatice Yıldırım and Mahmut Yıldız and Amaç Fatih Tuyun and Buket Alpertunga and Berna Özbek Çelik. “Investigation of Antimicrobial, Antibiofilm, and Cytotoxic Effects of Straight-Chained Sulfanyl Members of Arylamino-1,4-naphthoquinones as Potential Antimicrobial Agents.” European Journal of Biology 78, no. 2 (Nov. 2024): 117-123. https://doi.org/10.26650/EurJBiol.2019.0017


Harvard: Australian Style

Mataracı Kara, E & Jannuzzi, AT & Bayrak, N & Yıldırım, H & Yıldız, M & Tuyun, AF & Alpertunga, B & Özbek Çelik, B 2019, 'Investigation of Antimicrobial, Antibiofilm, and Cytotoxic Effects of Straight-Chained Sulfanyl Members of Arylamino-1,4-naphthoquinones as Potential Antimicrobial Agents', European Journal of Biology, vol. 78, no. 2, pp. 117-123, viewed 22 Nov. 2024, https://doi.org/10.26650/EurJBiol.2019.0017


Harvard: Author-Date Style

Mataracı Kara, E. and Jannuzzi, A.T. and Bayrak, N. and Yıldırım, H. and Yıldız, M. and Tuyun, A.F. and Alpertunga, B. and Özbek Çelik, B. (2019) ‘Investigation of Antimicrobial, Antibiofilm, and Cytotoxic Effects of Straight-Chained Sulfanyl Members of Arylamino-1,4-naphthoquinones as Potential Antimicrobial Agents’, European Journal of Biology, 78(2), pp. 117-123. https://doi.org/10.26650/EurJBiol.2019.0017 (22 Nov. 2024).


MLA

Mataracı Kara, Emel, and Ayşe Tarbın Jannuzzi and Nilüfer Bayrak and Hatice Yıldırım and Mahmut Yıldız and Amaç Fatih Tuyun and Buket Alpertunga and Berna Özbek Çelik. “Investigation of Antimicrobial, Antibiofilm, and Cytotoxic Effects of Straight-Chained Sulfanyl Members of Arylamino-1,4-naphthoquinones as Potential Antimicrobial Agents.” European Journal of Biology, vol. 78, no. 2, 2019, pp. 117-123. [Database Container], https://doi.org/10.26650/EurJBiol.2019.0017


Vancouver

Mataracı Kara E, Jannuzzi AT, Bayrak N, Yıldırım H, Yıldız M, Tuyun AF, Alpertunga B, Özbek Çelik B. Investigation of Antimicrobial, Antibiofilm, and Cytotoxic Effects of Straight-Chained Sulfanyl Members of Arylamino-1,4-naphthoquinones as Potential Antimicrobial Agents. European Journal of Biology [Internet]. 22 Nov. 2024 [cited 22 Nov. 2024];78(2):117-123. Available from: https://doi.org/10.26650/EurJBiol.2019.0017 doi: 10.26650/EurJBiol.2019.0017


ISNAD

Mataracı Kara, Emel - Jannuzzi, AyşeTarbın - Bayrak, Nilüfer - Yıldırım, Hatice - Yıldız, Mahmut - Tuyun, AmaçFatih - Alpertunga, Buket - Özbek Çelik, Berna. “Investigation of Antimicrobial, Antibiofilm, and Cytotoxic Effects of Straight-Chained Sulfanyl Members of Arylamino-1,4-naphthoquinones as Potential Antimicrobial Agents”. European Journal of Biology 78/2 (Nov. 2024): 117-123. https://doi.org/10.26650/EurJBiol.2019.0017



TIMELINE


Submitted23.07.2019
Accepted18.10.2019
Published Online06.12.2019

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