References

• Mathers CD, Loncar D. Projections of global mortality and bur-den of disease from 2002 to 2030. PLoS Med. 2006;3(11):e442. doi: 10.1371/journal.pmed.0030442. google scholar
• Global strategy for the diagnosis, management, and pre-vention of chronic obstructive pulmonary disease (updated 2022). GOLD. Available from: https://goldcopd.org/wp-content/uploads/2019/12/GOLD-2020-FINAL-ver1.2-03Dec19_WMV.pdf google scholar
• Hamilton KO, Yazdanian MA, Audus KL. Contribution of efflux pump activity to the delivery of pulmonary therapeutics. Curr Drug Metab. 2002;3(1):1-12. google scholar
• Lechapt-Zalcman E, Hurbain I, Lacave R, et al. MDR1-Pgp 170 expression in human bronchus. Eur Respir J. 1997;10(8):1837-1843. google scholar
• Scheffer GL, Pijnenborg AC, Smit EF, et al. Multidrug resistance related molecules in human and murine lung. J Clin Pathol. 2002;55(5):332-339. google scholar
• Hoffmeyer S, Burk O, von Richter O, et al. Functional poly-morphisms of the human multidrug-resistance gene: multi-ple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA. 2000;97(7):3473-3478. google scholar
• Cascorbi I, Gerloff T, Johne A, et al. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug trans-porter MDR1 gene in white subjects. Clin Pharmacol Ther. 2001;69(3):169-174. google scholar
• Tang K, Wong LP, Lee EJ, Chong SS, Lee CG. Genomic ev-idence for recent positive selection at the human MDR1 gene locus. Hum Mol Genet. 2004;13(8):783-797. google scholar
• Lehmann S, Bakke PS, Eide GE, Humerfelt S, Gulsvik A. Bronchodilator reversibility testing in an adult general popu-lation; the importance of smoking and anthropometrical vari-ables on the response to a beta2-agonist. Pulm Pharmacol Ther. 2006;19(4):272-280. google scholar
• Schermer T, Hejdra Y, Zadel S, et al. Flow and volume re-sponses after routine salbutamol reversibility testing in mild to very severe COPD. Respir Med. 2007;101(6):1355-1362. google scholar
• Miller M, Ramsdell J, Friedman PJ, Cho JY, Renvall M, Broide DH. Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: Eotaxin-1 is associated with bronchodilator response and extent of emphysema. J Allergy Clin Immunol. 2007;120(5):1118-1125. google scholar
• Izzotti A, Cartiglia C, Longobardi M, et al. Alterations of gene expression in skin and lung of mice exposed to light and cigarette smoke. FASEB J. 2004;18(13):1559-1561. google scholar
• Milojkovic M, Milacic N, Radovic J, Ljubisavljevic S. MDR1 gene polymorphisms and P-glycoprotein expression in respi-ratory diseases. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015;159(3):341-346. google scholar
• Ishikawa T, Hirano H, Onishi Y, Sakurai A, Tarui S. Func-tional evaluation of ABCB1 (P-glycoprotein) polymorphisms: High-speed screening and structure-activity relationship analy-ses. Drug Metab Pharmacokinet. 2004;19(1):1-14. google scholar
• Schwab M, Eichelbaum M, Fromm MF. Genetic polymorphisms of the human MDR1 drug transporter. Annu Rev Pharmacol Toxicol. 2003;43:285-307. google scholar
• Papp E, Gadawski I, Cöte HC. Longitudinal effects of thymi-dine analogues on mtDNA, mtRNA and multidrug resistance (MDR-1) induction in cultured cells. J Antimicrob Chemother. 2008;61(5):1048-1052. google scholar
• Israeli D, Ziaei S, Gonin P, Garcia L. A proposal for the physio-logical significance of mdr1 and Bcrp1/Abcg2 gene expression in normal tissue regeneration and after cancer therapy. J Theor Biol. 2005;232(1):41-45. google scholar
• van der Deen M, Marks H, Willemse BW, et al. Diminished ex-pression of multidrug resistance-associated protein 1 (MRP1) in bronchial epithelium of COPD patients. Virchows Arch. 2006;449(6):682-688. google scholar
• Gümüş-Akay G, Rüstemoğlu A, Karadağ A, Sunguroğlu A. Genotype and allele frequencies of MDR1 gene C1236T polymorphism in a Turkish population. Genet Mol Res. 2008;7(4):1193-1199. google scholar
• Dogan OT, Katrancioglu N, Karahan O, Sanli GC, Zorlu A, Manduz S. Frequency of the mdr-1 C>T gene polymorphism in patients with COPD. Clinics (Sao Paulo). 2010;65(11):1115-1117. google scholar
• Toru U, Ayada C, Genç O, Turgut S, Turgut G, Bulut I. MDR-1 gene C/T polymorphism in COPD: Data from Aegean part of Turkey. IntJ Clin Exp Med. 2014;7(10):3573-3577. google scholar
• Kimchi-Sarfaty C, Oh JM, Kim IW, et al. A "silent" polymor-phism in the MDR1 gene changes substrate specificity. Science. 2007;315(5811):525-528. google scholar
• Zhang X, Mahmudi-Azer S, Connett JE, et al. Association of Hck genetic polymorphisms with gene expression and COPD. Hum Genet. 2007;120(5):681-690. google scholar
• Hizawa N, Makita H, Nasuhara Y, et al. Beta2-adrenergic recep-tor genetic polymorphisms and short-term bronchodilator re-sponses in patients with COPD. Chest. 2007;132(5):1485-1492. google scholar
• Toru U, Ayada C, Genç O, Turgut S, Turgut G, Bulut I. MDR-1 gene C/T polymorphism in COPD: Data from Aegean part of Turkey. IntJ Clin Exp Med. 2014;7(10):3573-3577. google scholar
• Chernetska NV, Stupnytska HY, Fediv OI. The role of MDR1 (C3435T) gene polymorphism in patients with chronic obstruc-tive pulmonary disease associated with type 2 diabetes mellitus. J Med Life. 2020;13(3):349-355. google scholar

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