Research Article


DOI :10.26650/EurJBiol.2023.1328517   IUP :10.26650/EurJBiol.2023.1328517    Full Text (PDF)

Moringa oleifera Ethanolic Extract Prevents Oxidative Damage on Lens Caused by Sodium Valproate Used in Epilepsy Treatment

Eda DağsuyuUmar Faruk MagajiÖzlem SaçanRefiye Yanardağ

Objective: Valproic acid/valproate (VPA) is an antiepileptic agent that is structurally a short-chain fatty acid. It triggers the generation of reactive oxidants that can affect lens tissue. Moringa oleifera Lam. is a prevalent plant that grows in Asia, Africa and South Africa. The plant has anti-inflammatory, hepatoprotective, nephroprotective and cardioprotective activities.

Materials and Methods: The effect of 70% ethanol extract of the Moringa oleifera leaves was examined on VPA-induced lens tissue damage in this study. Experimental rats were grouped into four: the control (C), Moringa extract (M), VPA, and VPA+M group.Mextract and VPA respectively were administered orally at a dose of 0.3 and 0.5 grams per kg body weight daily for fifteen days. The lens tissues of the rats were taken after sacrifice. Oxidative stress markers including glutathione, lipid peroxidation, and advanced oxidation protein products levels, glutathione reductase, glutathione peroxidase, glutathione-S-transferase, and superoxide dismutase activities, total oxidant status, total antioxidant status, reactive oxygen species, nitric oxide levels and aldose reductase and sorbitol dehydrogenase activities were determined.

Results: Tissue homogenates showed a significant decrease in glutathione and total antioxidants, as well as an altered activity of superoxide dismutase and glutathione-related enzymes in VPA groups. Moreover, a significant rise in the concentration of nitric oxide, reactive oxygen species and total oxidants, coupled with higher aldose reductase and sorbitol dehydrogenase activities were detected. In contrast, changes in the levels of these parameters were offset in the VPA+M group by Moringa extract.

Conclusion: This suggests that Moringa oleifera leaves are an excellent nutritional composite for mitigating the damaging properties of VPA.


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APA

Dağsuyu, E., Magaji, U.F., Saçan, Ö., & Yanardağ, R. (2023). Moringa oleifera Ethanolic Extract Prevents Oxidative Damage on Lens Caused by Sodium Valproate Used in Epilepsy Treatment. European Journal of Biology, 82(2), 289-295. https://doi.org/10.26650/EurJBiol.2023.1328517


AMA

Dağsuyu E, Magaji U F, Saçan Ö, Yanardağ R. Moringa oleifera Ethanolic Extract Prevents Oxidative Damage on Lens Caused by Sodium Valproate Used in Epilepsy Treatment. European Journal of Biology. 2023;82(2):289-295. https://doi.org/10.26650/EurJBiol.2023.1328517


ABNT

Dağsuyu, E.; Magaji, U.F.; Saçan, Ö.; Yanardağ, R. Moringa oleifera Ethanolic Extract Prevents Oxidative Damage on Lens Caused by Sodium Valproate Used in Epilepsy Treatment. European Journal of Biology, [Publisher Location], v. 82, n. 2, p. 289-295, 2023.


Chicago: Author-Date Style

Dağsuyu, Eda, and Umar Faruk Magaji and Özlem Saçan and Refiye Yanardağ. 2023. “Moringa oleifera Ethanolic Extract Prevents Oxidative Damage on Lens Caused by Sodium Valproate Used in Epilepsy Treatment.” European Journal of Biology 82, no. 2: 289-295. https://doi.org/10.26650/EurJBiol.2023.1328517


Chicago: Humanities Style

Dağsuyu, Eda, and Umar Faruk Magaji and Özlem Saçan and Refiye Yanardağ. Moringa oleifera Ethanolic Extract Prevents Oxidative Damage on Lens Caused by Sodium Valproate Used in Epilepsy Treatment.” European Journal of Biology 82, no. 2 (Mar. 2024): 289-295. https://doi.org/10.26650/EurJBiol.2023.1328517


Harvard: Australian Style

Dağsuyu, E & Magaji, UF & Saçan, Ö & Yanardağ, R 2023, 'Moringa oleifera Ethanolic Extract Prevents Oxidative Damage on Lens Caused by Sodium Valproate Used in Epilepsy Treatment', European Journal of Biology, vol. 82, no. 2, pp. 289-295, viewed 3 Mar. 2024, https://doi.org/10.26650/EurJBiol.2023.1328517


Harvard: Author-Date Style

Dağsuyu, E. and Magaji, U.F. and Saçan, Ö. and Yanardağ, R. (2023) ‘Moringa oleifera Ethanolic Extract Prevents Oxidative Damage on Lens Caused by Sodium Valproate Used in Epilepsy Treatment’, European Journal of Biology, 82(2), pp. 289-295. https://doi.org/10.26650/EurJBiol.2023.1328517 (3 Mar. 2024).


MLA

Dağsuyu, Eda, and Umar Faruk Magaji and Özlem Saçan and Refiye Yanardağ. Moringa oleifera Ethanolic Extract Prevents Oxidative Damage on Lens Caused by Sodium Valproate Used in Epilepsy Treatment.” European Journal of Biology, vol. 82, no. 2, 2023, pp. 289-295. [Database Container], https://doi.org/10.26650/EurJBiol.2023.1328517


Vancouver

Dağsuyu E, Magaji UF, Saçan Ö, Yanardağ R. Moringa oleifera Ethanolic Extract Prevents Oxidative Damage on Lens Caused by Sodium Valproate Used in Epilepsy Treatment. European Journal of Biology [Internet]. 3 Mar. 2024 [cited 3 Mar. 2024];82(2):289-295. Available from: https://doi.org/10.26650/EurJBiol.2023.1328517 doi: 10.26650/EurJBiol.2023.1328517


ISNAD

Dağsuyu, Eda - Magaji, UmarFaruk - Saçan, Özlem - Yanardağ, Refiye. Moringa oleifera Ethanolic Extract Prevents Oxidative Damage on Lens Caused by Sodium Valproate Used in Epilepsy Treatment”. European Journal of Biology 82/2 (Mar. 2024): 289-295. https://doi.org/10.26650/EurJBiol.2023.1328517



TIMELINE


Submitted17.07.2023
Accepted10.08.2023
Published Online21.09.2023

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