Review Article


DOI :10.26650/EurJBiol.2023.1348427   IUP :10.26650/EurJBiol.2023.1348427    Full Text (PDF)

Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer

Christoffer B LambringLiling ChenClaire NelsonAlyssa StevensWynashia BratcherRiyaz Basha

Reactive oxygen species (ROS) are a class of bioactive molecules that are the by-products of many cellular functions. These molecules are present in normal cells at homeostatic levels but have been studied extensively in cancer due to their dysregulation resulting in pro- and anti-tumorigenic environments. Completely understanding the paradoxical nature of ROS in cancer is imperative to fully realize its modulation as cancer therapy. Studies into ROS have shown far-reaching effects in cancer, including how ROS levels regulate signaling, response to treatment, drug resistance, etc. Many drugs were studied with the hopes of regulating the ROS levels in cancer; however, patient response varied. Plant-derived medications offered new avenues of drug treatment over the last few decades, and the phytochemical Curcumin gained ground as an interesting cancer therapeutic. Curcumin is an active phenolic compound used in traditional medicine around the world. Although it suffers from a poor pharmacokinetic profile, Curcumin exerts anti-tumorigenic, as well as ROS-modulating activities. Analogs and derivatives of Curcumin are under development to improve upon its anti-cancer properties and enhance its bioavailability, currently a major limitation of its usage. This review highlights ROS function in cancer treatment focused on ROS, including Curcumin and its analogs.


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APA

Lambring, C.B., Chen, L., Nelson, C., Stevens, A., Bratcher, W., & Basha, R. (2023). Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer. European Journal of Biology, 82(2), 317-325. https://doi.org/10.26650/EurJBiol.2023.1348427


AMA

Lambring C B, Chen L, Nelson C, Stevens A, Bratcher W, Basha R. Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer. European Journal of Biology. 2023;82(2):317-325. https://doi.org/10.26650/EurJBiol.2023.1348427


ABNT

Lambring, C.B.; Chen, L.; Nelson, C.; Stevens, A.; Bratcher, W.; Basha, R. Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer. European Journal of Biology, [Publisher Location], v. 82, n. 2, p. 317-325, 2023.


Chicago: Author-Date Style

Lambring, Christoffer B, and Liling Chen and Claire Nelson and Alyssa Stevens and Wynashia Bratcher and Riyaz Basha. 2023. “Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer.” European Journal of Biology 82, no. 2: 317-325. https://doi.org/10.26650/EurJBiol.2023.1348427


Chicago: Humanities Style

Lambring, Christoffer B, and Liling Chen and Claire Nelson and Alyssa Stevens and Wynashia Bratcher and Riyaz Basha. Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer.” European Journal of Biology 82, no. 2 (Mar. 2024): 317-325. https://doi.org/10.26650/EurJBiol.2023.1348427


Harvard: Australian Style

Lambring, CB & Chen, L & Nelson, C & Stevens, A & Bratcher, W & Basha, R 2023, 'Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer', European Journal of Biology, vol. 82, no. 2, pp. 317-325, viewed 3 Mar. 2024, https://doi.org/10.26650/EurJBiol.2023.1348427


Harvard: Author-Date Style

Lambring, C.B. and Chen, L. and Nelson, C. and Stevens, A. and Bratcher, W. and Basha, R. (2023) ‘Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer’, European Journal of Biology, 82(2), pp. 317-325. https://doi.org/10.26650/EurJBiol.2023.1348427 (3 Mar. 2024).


MLA

Lambring, Christoffer B, and Liling Chen and Claire Nelson and Alyssa Stevens and Wynashia Bratcher and Riyaz Basha. Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer.” European Journal of Biology, vol. 82, no. 2, 2023, pp. 317-325. [Database Container], https://doi.org/10.26650/EurJBiol.2023.1348427


Vancouver

Lambring CB, Chen L, Nelson C, Stevens A, Bratcher W, Basha R. Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer. European Journal of Biology [Internet]. 3 Mar. 2024 [cited 3 Mar. 2024];82(2):317-325. Available from: https://doi.org/10.26650/EurJBiol.2023.1348427 doi: 10.26650/EurJBiol.2023.1348427


ISNAD

Lambring, ChristofferB - Chen, Liling - Nelson, Claire - Stevens, Alyssa - Bratcher, Wynashia - Basha, Riyaz. Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer”. European Journal of Biology 82/2 (Mar. 2024): 317-325. https://doi.org/10.26650/EurJBiol.2023.1348427



TIMELINE


Submitted23.08.2023
Accepted19.09.2023
Published Online17.11.2023

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