BÖLÜM


DOI :10.26650/B/CH12CH47.2023.014.20   IUP :10.26650/B/CH12CH47.2023.014.20    Tam Metin (PDF)

Yaşlılık Ve Akut Böbrek Yetmezli̇ği̇

Feyza Bayrakdar ÇağlayanSiren Sezer

Yaşlanma, kişide fonksiyonel rezervlerde ilerleyici azalma ile iç ve dış kaynaklı strese adapte olma kapasitesinde bozulma halidir. Bu durum hastalık ve ölüm riskinde artışa sebep olmaktadır. Günümüzde, sağlık hizmetlerine erişimin yaygınlaşması ve tıbbi imkanların gelişmesi ile yaşlı nüfusun giderek artıyor olması, klinik uygulamalarda yeni yaklaşımları zorunlu kılmaktadır. Akut böbrek hasarı (ABH) özellikle yoğun bakım ünitelerinde olmak üzere yaşlı hastalarda sıklıkla görülen böbrek fonksiyonlarında ani azalma ile karakterize kritik bir durumdur. Kısa ve uzun dönem mortalite, hastane yatışı artışına neden olur ve kronik böbrek yetmezliğinin bir göstergesi olarak kabul edilir. Diyabet, hipertansiyon ve kalp hastalıkları gibi komorbiditelerden bir veya birkaçına sahip ve çoklu ilaç kullanımı olan yaşlı popülasyonda ABH daha sık görülmektedir Sıklığı ve önemi göz önüne alındığında yaşlılarda ABH’dan korunma ve tedavisinin bilinmesi dahiliye ve acil kliniklerinde önemli yer tutmaktadır.



Referanslar

  • 1. Chawla, L.S.; Bellomo, R.; Bihorac, A.; Goldstein, S.L.; Siew, E.D.; Bagshaw, S.M.; Bittleman, D.; Cruz, D.; Endre, Z.; Fitzgerald, R.L.; et al. Acute Kidney Disease and Renal Recovery: Consensus Report of the Acute Disease Quality Initiative (ADQI) 16 Work group. Nat. Rev. Nephrol. 2017, 13, 241-257. google scholar
  • 2. Bellomo R, Ronco C, Kellum JA, et al. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. CritCare 2004;8(4):R204-12. google scholar
  • 3. Mehta RL, Kellum JA, Shah SV, et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acutekidneyinjury. CritCare 2007;11(2):R31. google scholar
  • 4. Ali T, Khan I, Simpson W, et al. Incidence and outcomes in acute kidney injury: a comprehensive popula-tion-basedstudy. J AmSocNephrol 2007; 18: 1292-1298. google scholar
  • 5. Kellum, J. A., Lameire, N., Aspelin, P., Barsoum, R. S., Burdmann, E. A., Goldstein, S. L., ... &Uchino, S. (2012). Kidney disease: improving global outcomes (KDIGO) acute kidney injury working group. KDIGO clinical practice guideline for acute kidney injury. Kidney international supplements, 2(1), 1-138. google scholar
  • 6. Thakar CV, Christianson A, Freyberg R, et al. Incidence and outcomes of acute kidney injury in intensive care units: a Veterans Administration study. CritCareMed 2009; 37: 2552-2558. google scholar
  • 7. Joannidis M, Metnitz B, Bauer P, et al. Acute kidney injury in critically ill patients classified by AKIN versus RIFLE using the SAPS 3 database. IntensiveCareMed 2009; 35: 1692-1702. google scholar
  • 8. Ostermann M, Chang RW. Acute kidney injury in the intensive care unit accordingto RIFLE. CritCareMed 2007; 35: 1837-1843. google scholar
  • 9. Rosner, M. H., & Bolton, W. K. (2006). Renal function testing. AmericanJournal of KidneyDiseases, 47(1), 174-183. google scholar
  • 10. Swedko, P. J., Clark, H. D., Paramsothy, K., &Akbari, A. (2003). Serum creatinine is an inadequate scre-ening test for renal failure in elderly patients. Archives of internalmedicine, 163(3), 356-360. google scholar
  • 11. Levin, A., Stevens, P. E., Bilous, R. W., Coresh, J., De Francisco, A. L., De Jong, P. E., ... &Winearls, C. G. (2013). KidneyDisease: Improving Global Outcomes (KDIGO) CKD WorkGroup. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney international supplements, 3(1), 1-150. google scholar
  • 12. Hallan, S.I., Gansevoort, R.T., 2013. Moderator’s view: estimation of glomerular filtration rate - the past, present andf uture. Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association 28, 1404-1406. google scholar
  • 13. Glassock, Richard J., and Andrew D. Rule. “The implications of anatomical and functional changes of the aging kidney: with an emphasis on theglomeruli.” Kidney international 82.3 (2012): 270-277. google scholar
  • 14. Schaeffner ES, Ebert N, Delanaye P, Frei U, Gaedeke J, Jakob O, Kuhlmann MK, Schuchardt M, Tölle M, Ziebig R, van der Giet M, Martus P: Two Novel Equations to Estimate Kidney Function in Persons Aged 70 Years or Older. Annals of InternalMedicine2012;157:471-481. google scholar
  • 15. Bolignano, D., Mattace-Raso, F., Sijbrands, E. J., &Zoccali, C. (2014). The aging kidney revisited: a sys-tematic review. Ageing research reviews, 14, 65-80. google scholar
  • 16. Coca SG, Yalavarthy R, Concato J, et al. Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review. KidneyInt 2008;73(9): 1008-16. google scholar
  • 17. Waikar SS, Bonventre JV. Biomarkers for the diagnosis of acute kidney injury. Nephron Clin Pract 2008;109(4):c192-7. 46. google scholar
  • 18. AfC, L. (2020). profile of olderAmericans. US department of healthandhumanservices. google scholar
  • 19. Martin, N., Beach, D., &Gil, J. (2014). Ageing as developmental decay: insights from p16INK4a. Trends in molecularmedicine, 20(12), 667-674. google scholar
  • 20. TÜİK, 2018. Nüfus Projeksiyonları,2025-2080. https://data.tuik.gov.tr/ google scholar
  • 21. Hsu CY, Chertow GM, McCulloch CE, Fan D, Ordonez JD, Go AS: Nonrecovery of kidney function and death after acute on chronic renal failure. Clin J AmSocNephrol 2009;4: 891-898 google scholar
  • 22. Bellomo, R., Kellum, J. A., &Ronco, C. (2012). Acute kidney injury. The Lancet, 380(9843), 756-766. google scholar
  • 23. Saran, R., Robinson, B., Abbott, K. C., Agodoa, L. Y., Albertus, P., Ayanian, J., ... &Shahinian, V. (2017). US renal data system 2016 annual data report: epidemiology of kidney disease in the United States. Ame-rican journal of kidney diseases, 69(3), A7-A8. google scholar
  • 24. Chao, C. T., Lin, Y. F., Tsai, H. B., Wu, V. C., &Ko, W. J. (2013). Acute kidney injury network staging in geriatric postoperative acute kidney injury patients: shortcomingsandimprovements. Journal of theAmeri-can College of Surgeons, 217(2), 240-250. google scholar
  • 25. Schmitt, R., Coca, S., Kanbay, M., Tinetti, M. E., Cantley, L. G., &Parikh, C. R. (2008). Recovery of kid-neyfunctionafteracutekidneyinjury in theelderly: a systematicreviewand meta-analysis. AmericanJournal of KidneyDiseases, 52(2), 262-271. google scholar
  • 26. Wald, R., Quinn, R. R., Luo, J., Li, P., Scales, D. C., Mamdani, M. Met al. University of Toronto Acute Kidney Injury Research Group. (2009). Chronic dialysis and death among survivors of acute kidney injury requiring dialysis. Jama, 302(11), 1179-1185. google scholar
  • 27. Macedo, E., Bouchard, J., & Mehta, R. L. (2008). Renal recovery following acut ekidney injury. Current opinion in criticalcare, 14(6), 660-665. google scholar
  • 28. Infante, B., Franzin, R., Madio, D., Calvaruso, M., Maiorano, A., Sangregorio, F., ... &Stallone, G. (2020). Molecular mechanisms of AKI in the elderly: from animal models to therapeutic intervention. Journal of Clinical Medicine, 9(8), 2574. google scholar
  • 29. Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, Van LF, Levey AS: Prevalence of chronic kidney disease in the United States. JAMA 2007;298:2038-2047. google scholar
  • 30. Long, D.A.; Mu, W.; Price, K.L.; Johnson, R.J. Blood Vessels and the Aging Kidney. Nephron. Exp. Neph-rol. 2005, 101, 95-99 google scholar
  • 31. Zappitelli, M. Epidemiology and Diagnosis of Acute Kidney Injury. Semin. Nephrol. 2008, 28, 436446 google scholar
  • 32. Hoste, E.A.J.; Kellum, J.A.; Selby, N.M.; Zarbock, A.; Palevsky, P.M.; Bagshaw, S.M.; Goldstein, S.L.; Cerda, J.; Chawla, L.S. Global EpidemiologyandOutcomes of AcuteKidneyInjury. Nat. Rev. Nephrol. 2018, 14, 607-625 google scholar
  • 33. Yokota, L.G.; Sampaio, B.M.; Rocha, E.P.; Balbi, A.L.; SousaPrado, I.R.; Ponce, D. AcuteKidneyInjury in ElderlyPatients: NarrativeReview on Incidence, Risk Factors, andMortality. Int. J. Nephrol. Renovasc. Dis. 2018, 11, 217-224 google scholar
  • 34. Silva, F.G. Theagingkidney: A review—Part I. Int. Urol. Nephrol. 2005; 37:185-205. google scholar
  • 35. Bax, L., van der Fraaf, Y., Rabelink, A.J., Algra, A., Beutler, J.J., Mali, W.P.; SMART StudyGroup. Influen-ce of atherosclerosis on age-related changes in renal size and function. Eur. J. Clin. Invest 2003; 22:34-40. google scholar
  • 36. Newbold KM, Sandison A, Howie AJ: Comparison of size of juxtamedullary and outer corti-cal glomeruli in normal adult kidney. VirchowsArch A Pathol Anat Histopathol 420: 127-129, 1992pmid:1549901 google scholar
  • 37. Nyengaard JR, Bendtsen TF: Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec 232: 194-201, 1992 mid:1546799) google scholar
  • 38. Jeffrey BH, Joseph GO, Mary T, Stephanie S, Kevin PH, Sanjay A. Hazzard’sGeriatric Medicine and Gerontology. 6th ed. USA: McGrawHill; 2009. google scholar
  • 39. Rowe J, Andres R, Tobin J, Norris AH, Shock NW. The effect of age on creatinine clearance in men: A crosssectional and longitudinal study. J Gerontol 1976; 31: 155-63. google scholar
  • 40. A. Denic, J.C. Lieske, H.A. Chakkera, E.D. Poggio, M.P. Alexander, P. Singh, W.K. Kremers, L.O. Ler-man, A.D. RuleThesubstantialloss of nephrons in healthy human kidneys with aging J. Am. Soc. Neph-rol., 28 (2017), pp. 313-320 . google scholar
  • 41. Davies D, Shock N. Age changes in glomerularfiltration rate, effective renal plasma flow, and tubula rexcretory capacity in adultmales. J Clin Invest 1950; 29: 496-507. google scholar
  • 42. Hill GS, Heudes D, Jacquot C, Gauthier E, Bariety J: Morphometric evidence for impairment of renal autoregulation in advanced essential hypertension. KidneyInt2006;69:823-831. google scholar
  • 43. Hollenberg NK, Adams DF, olomon HS, Rashid ABDU, Abrams HL, Merrill JP: Senescence and the Renal Vasculature in Normal Man. CircRes 1974;34:309-316. google scholar
  • 44. O’Sullivan, E. D., Hughes, J., &Ferenbach, D. A. (2017). Renal aging: causes and consequences. Journal of the American Society of Nephrology, 28(2), 407-420. google scholar
  • 45. Rosner, M. H. (2009). Acute kidney injury in the elderly: pathogenesis, diagnosis and therapy. Aging Health, 5(5), 635-646. google scholar
  • 46. Chronopoulos, A.; Cruz, D.N.; Ronco, C. Hospital-Acquired Acute Kidney Injury in the Elderly. Nat. Rev. Nephrol. 2010, 6, 141-149 google scholar
  • 47. Mooradian, A.D. Evidence-Based Management of Diabetes in OlderAdults. DrugsAging 2018, 35, 10651078. google scholar
  • 48. Da Silveira Santos, C.G.; Romani, R.F.; Benvenutti, R.; RibasZahdi, J.O.; Riella, M.C.; Mazza do Nasci-mento, M. Acute Kidney Injury in Elderly Population: A Prospective Observational Study. Nephron 2018, 138, 104-112. google scholar
  • 49. Shah, B.R.; Hux, J.E. Quantifyingthe Risk of Infectious Diseases for People with Diabetes. Diabetes Care 2003, 26, 510-513 google scholar
  • 50. Davison, B.A.; Metra, M.; Cotter, G.; Massie, B.M.; Cleland, J.G.F.; Dittrich, H.C.; Edwards, C.; Filip-patos, G.; Givertz, M.M.; Greenberg, B.; et al. Worsening Heart Failure Following Admission for Acute Heart Failure: A Pooled Analysis of the PROTECT and RELAX-AHF Studies. JACC Heart Fail. 2015, 3, 395-403 google scholar
  • 51. Shirakabe, A.; Hata, N.; Kobayashi, N.; Okazaki, H.; Matsushita, M.; Shibata, Y.; Uchiyama, S.; Sawatani, T.; Asai, K.; Shimizu, W. Worsening Renal Failure in Patients with Acute Heart Failure: The Importance of Cardiac Biomarkers. ESC Heart Fail. 2019, 6, 416-427. google scholar
  • 52. Feest TG, Round A, Hamad S (1993) Incidence of severe acute renal failure in adults: results of a commu-nity based study. BrMed J 306:481-483 google scholar
  • 53. Cheung CM, Ponnusamy A, Anderton JG (2008) Management of acute renal failure in the elderly patient: a clinician’s guide. Drugs Aging 25:455-476 google scholar
  • 54. Aymanns C, Keller F, Maus S, Hartmann B, Czock D (2010) Review on pharmacokinetics and pharmaco dynamics and the aging kidney. Clin J Am So cNephrol 5:314-327 google scholar
  • 55. Chao, C.-T.; Tsai, H.-B.; Wu, C.-Y.; Lin, Y.-F.; Hsu, N.-C.; Chen, J.-S.; Hung, K.-Y. Cumulative Cardio-vascular Polypharmacy Is Associated With the Risk of Acute Kidney Injury in Elderly Patients. Medicine 2015, 94, e1251. google scholar
  • 56. Mallappallil, M.; Sabu, J.; Friedman, E.A.; Salifu, M. What Do We Know about Opioids and the Kidney? Int. J. Mol. Sci. 2017, 18, 223. google scholar
  • 57. Chau, D.L.; Walker, V.; Pai, L.; Cho, L.M. Opiates and Elderly: Use and Side Effects. Clin. Interv. Aging 2008, 3, 273-278. google scholar
  • 58. Heyman, S.N.; Rosenberger, C.; Rosen, S. Regional Alterations in Renal Haemodynamics and Oxygena-tion: A Role in Contrast Medium-Induced Nephropathy. Nephrol. Dial. Transplant. 2005, 20 (Suppl. S1), i6-i11. google scholar
  • 59. Bagshaw, S.M.; Uchino, S.; Bellomo, R.; Morimatsu, H.; Morgera, S.; Schetz, M.; Tan, I.; Bouman, C.; Macedo, E.; Gibney, N.; et al. Septic Acute Kidney Injury in Critically Ill Patients: Clinical Characteristics and Outcomes. Clin. J. Am. Soc. Nephrol. 2007, 2, 431-439. google scholar
  • 60. Valentijn, F.A.; Falke, L.L.; Nguyen, T.Q.; Goldschmeding, R. Cellular Senescence in the Aging and Di-seased Kidney. J. Cell Commun. Signal. 2018, 12, 69-82 google scholar
  • 61. Rosner, M. H., La Manna, G., &Ronco, C. (2018). Acute kidney injury in the geriatric population. In Acute Kidne yInjury-Basic Research and Clinical Practice (Vol. 193, pp. 149-160). KargerPublishers. google scholar
  • 62. Waikar SS, Bonventre JV: Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol 2009;20:672-679. google scholar
  • 63. Soni, S.S.; Cruz, D.; Bobek, I.; Chionh, C.Y.; Nalesso, F.; Lentini, P.; de Cal, M.; Corradi, V.; Virzi, G.; Ronco, C. NGAL: A Biomarker of Acute Kidney Injury and Other Systemic Conditions. Int. Urol. Nephrol. 2010, 42, 141-150. google scholar
  • 64. Shlipak, M.G.; Sarnak, M.J.; Katz, R.; Fried, L.F.; Seliger, S.L.; Newman, A.B.; Siscovick, D.S.; Steh-man-Breen, C. Cystatin C and the Risk of Death and Cardiovascular Events among Elderly Persons. N. Engl. J. Med. 2005, 352, 2049-2060. google scholar
  • 65. Parikh, C.R.; Abraham, E.; Ancukiewicz, M.; Edelstein, C.L. Urine IL-18 Is an Early Diagnostic Marker for Acute Kidney Injury and Predicts Mortality in the Intensive Care Unit. J. Am. Soc. Nephrol. 2005, 16, 3046-3052. google scholar
  • 66. Siew, E.D.; Ware, L.B.; Gebretsadik, T.; Shintani, A.; Moons, K.G.M.; Wickersham, N.; Bossert, F.; Ikiz-ler, T.A. Urine Neutrophil Gelatinase-Associated Lipocalin Moderately Predicts Acute Kidney Injury in Critically ill Adults. J. Am. Soc. Nephrol. 2009, 20, 1823-1832. google scholar
  • 67. Han, W.K.; Wagener, G.; Zhu, Y.; Wang, S.; Lee, H.T. Urinary Biomarkers in the Early Detection of Acute Kidney Injury after Cardiac Surgery. Clin. J. Am. Soc. Nephrol. 2009, 4, 873-882. google scholar
  • 68. Park, H.S.; Kim, J.W.; Lee, K.R.; Hong, D.Y.; Park, S.O.; Kim, S.Y.; Kim, J.Y.; Han, S.K. Urinary Neut-rophil Gelatinase-Associated Lipocalin as a Biomarker of Acut eKidneyInjury in Sepsis Patients in the Emergency Department. Clin. Chim. Acta 2019, 495, 552-555. google scholar
  • 69. Khwaja, A. KDIGO Clinical Practice Guidelines for Acute Kidney Injury. Nephron. Clin. Pract. 2012, 120, c179-c184. google scholar
  • 70. Fiaccadori, E.; Regolisti, G.; Cademartiri, C.; Cabassi, A.; Picetti, E.; Barbagallo, M.; Gherli, T.; Cas-tellano, G.; Morabito, S.; Maggiore, U. Efficacy and Safety of a Citrate-Based Protocol for Sustained Low-Efficiency Dialysis in AKI Using Standard Dialysis Equipment. Clin. J. Am. Soc. Nephrol. 2013, 8, 1670-1678. google scholar
  • 71. Uchino, S.; Kellum, J.A.; Bellomo, R.; Doig, G.S.; Morimatsu, H.; Morgera, S.; Schetz, M.; Tan, I.; Bouman, C.; Macedo, E.; et al. Acute Renal Failure in Critically Ill Patients: A Multinational, Multicenter Study. JAMA 2005, 294, 813-818. google scholar
  • 72. Pascual, J.; Liano, F.; Ortuno, J. The Elderly Patient with Acute Renal Failure. J. Am. Soc. Nephrol. 1995, 6, 144-153. google scholar
  • 73. Bagshaw, S.M.; Laupland, K.B.; Doig, C.J.; Mortis, G.; Fick, G.H.; Mucenski, M.; Godinez-Luna, T.; Svenson, L.W.; Rosenal, T. PrognosisforLong-Term Survival and Renal Recovery in Critically Ill Patients with Severe Acute Renal Failure: A Population-Based Study. Crit. Care 2005, 9, R700-R709 google scholar
  • 74. Li, Q.; Zhao, M.; Du, J.; Wang, X. Outcomes of Renal Function in Elderly Patients with Acute Kidney Injury. Clin. Interv. Aging 2017, 12, 153-160. google scholar
  • 75. Bhandari S, Turney JH: Survivors of acute renal failure who do not recover renal function. QJM 1996;89:415-421. 55 google scholar
  • 76. Schiffl H: Renal recovery from acute tubular necrosis requiring renal replacement therapy: a prospective study in critically ill patients. Nephrol Dial Transplant 2006;21:1248-1252. google scholar
  • 77. Liano F, Felipe C, Tenorio MT, et al: Long term outcome of acute tubular necrosis: a contribution to its natural history. Kidney Int2007;71:679-686. google scholar
  • 78. Schmitt R, Coca S, Kanbay M, Tinetti ME, Cantley LG, Parikh CR: Recovery of kidney function after acu-te kidney injury in the elderly: a systematic review and meta-analysis. Am J Kidney Dis 2008;52:262-271. google scholar
  • 79. James, M.T.; Ghali, W.A.; Tonelli, M.; Faris, P.; Knudtson, M.L.; Pannu, N.; Klarenbach, S.W.; Manns, B.J.; Hemmelgarn, B.R. Acute Kidney Injury Following CoronaryAngiography Is Associated with a Long-Term Decline in Kidney Function. Kidney Int. 2010, 78, 803-809. google scholar


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