Referanslar

• Hirsch FR, Scagliotti GV, Mulshine JL, et al. Lung can-cer: current therapies and new targeted treatments. Lancet. 2017;389(10066):299-311. google scholar
• Oser MG, Niederst MJ, Sequist LV, Engelman JA. Transformation from non-small-cell lung cancer to small-cell lung cancer: Molec-ular drivers and cells of origin. Lancet Oncol. 2015;16(4):e165-e172. doi:10.1016/S1470-2045(14)71180-5 google scholar
• Zappa C, Mousa, SA. Non-small cell lung cancer: Cur-rent treatment and future advances. Transl Lung Cancer Res. 2016;5(3):288. doi:10.21037/tlcr.2016.06.07 google scholar
• Li N, Mai Y, Liu Q, Gou G, Yang J. Docetaxel-loaded D-a-tocopheryl polyethylene glycol-1000 succinate liposomes im-prove lung cancer chemotherapy and reverse multidrug resistance. Drug Deliv Transl Res. 2021;11:131-141. google scholar
• Lynch TJ, Kass F, Elias AD, et al. Cisplatin, 5-fluorouracil, and etoposide for advanced non-small cell lung cancer. Cancer. 1993;71(10):2953-2957. google scholar
• Zhang M, Li M, Du L, Zeng J, Yao T, Jin Y. Paclitaxel-in-liposome-in-bacteria for inhalation treatment of primary lung cancer. Inter J Pharm. 2020;578:119177. doi: 10.1016/j.ijpharm.2020.119177 google scholar
• Storz P. Mitochondrial ROS-radical detoxification, mediated by protein kinase D. Trends Cell Bio. 2007;17(1):13-18. google scholar
• Prakash O, Kumar A, Kumar P, Ajeet. Anticancer potential of plants and natural products. Am J Pharmacol Sci. 2013;1(6):104-115. google scholar
• Hyun TK, Kim HC, Ko YJ, Kim JS. Antioxidant, a-glucosidase inhibitory and anti-inflammatory effects of aerial parts extract from Korean crowberry (Empetrum nigrum var. japonicum). Saudi J Bio Sci. 2016;23(2):181-188. google scholar
• George BP, Abrahamse H. Traditional uses and bioactivities of common Rubus species with reference to cancer: A mini-review. Phyto:Pot Ther Appl. 2021;259-270. google scholar
• Tuzlacı E. Türkiye Bitkileri Geleneksel İlaç Rehberi (Turkey’s Plants Traditional Medicine Guide), First ed. İstanbul: İstanbul Tıp Kitabevleri Press; 2016. google scholar
• Gudej J, Tomczyk M. Determination of flavonoids, tannins and ellagic acid in leaves from Rubus L. species. Arch Pharm Res. 2004;(27):1114-1119. google scholar
• Wolniak M, Tomczykowa M, Tomczyk M, Gudej J, Wawer I. An-tioxidant activity of extracts and flavonoids from Bidens tripartita. Acta Poloniae Pharm. 2007; 64(5): 441-447. google scholar
• Sen A, Ozbeyli D, Teralı K, et al. Protective effects of Rubus tereticaulis leaves ethanol extract on rats with ulcerative colitis and bio-guided isolation of its active compounds: A com-bined in silico, in vitro and in vivo study. Chemico-Bio Inter. 2023;369:110263. doi:10.1016/j.cbi.2022.110263 google scholar
• Aksoy H, Demirbag C, Sen A, et al. Evaluation of biochemical parameters in Rubus tereticaulis treated rats and its implications in wound healing. Mol Cell Biochem. 2020; 472:67-78. google scholar
• Kocyigit A, Guler EM, Karatas E, Caglar H, Bulut H. Dose-dependent proliferative and cytotoxic effects of melatonin on hu-man epidermoid carcinoma and normal skin fibroblast cells. Mut Res Genet Toxico Envir Mutag. 2018;829:50-60. google scholar
• Wu T, Qiang L, Chen FH, et al. LFG-500, a newly synthe-sized flavonoid, induced a reactive oxygen species-mitochondria-mediated apoptosis in hepatocarcinoma cells. Bio Preven Nutr. 2011;1(2):132-138. google scholar
• Mcgahon AJ, Martin SJ, Bissonnette RP, et al. The end of the (cell) line: Methods for the study of apoptosis in vitro. Method Cell Biol. 1995;46:153-185. google scholar
• Wen T, Song L, Hua S. Perspectives and controversies regarding the use of natural products for the treatment of lung cancer. Cancer Med. 2021;10(7):2396-2422. google scholar
• Zhao X, Song J, Lee JH, Kim SY, Park KY. Antioxidation and cancer cell (HT-29) antiproliferation effects of Rubus coreanus Miquel bamboo salt. J Cancer Prev. 2010; 15(4):306-312. google scholar
• Kim EJ, Lee YJ, Shin HK, Park JHY. Induction of apoptosis by the aqueous extract of Rubus coreanum in HT-29 human colon cancer cells. Nutrition. 2005;21(11-12):1141-1148. google scholar
• Saikolappan S, Kumar B, Shishodia G, Koul S, Koul HK. Reactive oxygen species and cancer: A complex interaction. Cancer Lett. 2019;452:132-143. google scholar
• Simon HU, Haj-Yehia A, Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis. 2000;5:415-418. google scholar
• Kocyigit A, Koyuncu I, Taskin A, Dikilitas M, Bahadori F, Turkkan B. Antigenotoxic and antioxidant potentials of newly derivatized compound naringenin-oxime relative to naringenin on human mononuclear cells. Drug Chem Toxicol. 2016;39(1):66-73. google scholar
• George BP, Abrahamse H. Increased oxidative stress induced by rubus bioactive compounds induce apoptotic cell death in hu-man breast cancer cells. Oxid Med Cell Longev. 2019;6797921. doi:10.1155/2019/6797921 google scholar
• Lavrik IN, Golks A, Krammer PH. Caspases: Pharmacological manipulation of cell death. J Clinic Inves. 2005;115(10):2665-2672. google scholar
• Galluzzi L, Maiuri MC, Vitale I, et al. Cell death modalities: Classification and pathophysiological implications. Cell Death Differ. 2007;14(7):1237-1243. google scholar
• Plackal Adimuriyil George B, Tynga IM, Abrahamse H. In vitro antiproliferative effect of the acetone extract of Rubus fairholmianus gard. Root on human colorectal cancer cells. BioMed Res Inter. 2015;2015:165037. doi:10.1155/2015/165037 google scholar
• Erel SB, Demir S, Nalbantsoy A, et al. Bioactivity screening of five Centaurea species and in vivo anti-inflammatory activity of C. athoa. Pharm Biol. 2014;52(6):775-781. google scholar
• Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420(6917):860-867. google scholar
• Morrıson WB. Inflammation and cancer: A comparative view. J Vet Int Med. 2012; 26(1):18-31. google scholar
• Rayburn ER, Ezell SJ, Zhang R. Anti-inflammatory agents for cancer therapy. Mol Cell Pharm. 2009;1(1):29-43. google scholar
• Kawamori T, Lubet R, Steele VE, et al. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res. 1999;59(3):597-601. google scholar
• Muller AG, Sarker SD, Saleem IY, Hutcheon GA. Delivery of natural phenolic compounds for the potential treatment of lung cancer. DARU J Pharma Sci. 2019;27: 433-449. google scholar
• Amararathna M, Johnston MR, Rupasinghe HPV. Plant polyphe-nols as chemopreventive agents for lung cancer. Inter J Mol Sci. 2016;17(8):1352. doi:10.3390/ijms17081352 google scholar
• Murakami A, Ashida H, Terao J. Multitargeted cancer prevention by quercetin. Cancer Lett. 2008;269(2):315-325. google scholar

Atıflar