Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion
Gabriel Pereira, Emily Pereira Dos Santos, Maria Augusta Ruy Barbosa, Sofía Tomaselli Arioni, Thabata Caroline De Oliveira Santos, Débora Tavares De Resende E Silva, Juan Sebastian Henao Agudelo, Maria Do Carmo Pinho Franco, Ricardo Fernandez, Rafael Luiz Pereira, Danilo Cândido De AlmeidaChronic Kidney Disease (CKD) affects millions of people worldwide and is a global health problem with few treatment options. The mechanisms underlying the pathogenesis of CKD include oxidative damage and inflammation. Damage to the glomeruli may be observed during the course of co-associated diseases such diabetes, but also in specific conditions such as focal segmental glomerulosclerosis. During its early manifestation, podocyte’s damage and death are key factors to glomerulopathies and its protection may represent an important therapeutic approach. Importantly, podocytes pathology involves inflammation and cellular damage, principally due to excessive oxidative stress. Underlying mechanisms associated to both inflammation and oxidative stress during the course of a renal lesion must be elucidated for the development of better clinical and research approaches to kidney physiology. Thus, here we discuss the role of the Thioredoxin system, an antioxidant mechanism, and TXNIP, a thioredoxin inhibitor linked to NRLP3 inflammasome activation, as a pivotal axis in the pathophysiology of glomerular lesions.
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DIŞA AKTAR
APA
Pereira, G., Pereira Dos Santos, E., Ruy Barbosa, M.A., Arioni, S.T., De Oliveira Santos, T.C., De Resende E Silva, D.T., Henao Agudelo, J.S., Pinho Franco, M.D., Fernandez, R., Pereira, R.L., & De Almeida, D.C. (2022). Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion. European Journal of Biology, 81(2), 274-280. https://doi.org/10.26650/EurJBiol.2022.1163544
AMA
Pereira G, Pereira Dos Santos E, Ruy Barbosa M A, Arioni S T, De Oliveira Santos T C, De Resende E Silva D T, Henao Agudelo J S, Pinho Franco M D, Fernandez R, Pereira R L, De Almeida D C. Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion. European Journal of Biology. 2022;81(2):274-280. https://doi.org/10.26650/EurJBiol.2022.1163544
ABNT
Pereira, G.; Pereira Dos Santos, E.; Ruy Barbosa, M.A.; Arioni, S.T.; De Oliveira Santos, T.C.; De Resende E Silva, D.T.; Henao Agudelo, J.S.; Pinho Franco, M.D.; Fernandez, R.; Pereira, R.L.; De Almeida, D.C. Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion. European Journal of Biology, [Publisher Location], v. 81, n. 2, p. 274-280, 2022.
Chicago: Author-Date Style
Pereira, Gabriel, and Emily Pereira Dos Santos and Maria Augusta Ruy Barbosa and Sofía Tomaselli Arioni and Thabata Caroline De Oliveira Santos and Débora Tavares De Resende E Silva and Juan Sebastian Henao Agudelo and Maria Do Carmo Pinho Franco and Ricardo Fernandez and Rafael Luiz Pereira and Danilo Cândido De Almeida. 2022. “Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion.” European Journal of Biology 81, no. 2: 274-280. https://doi.org/10.26650/EurJBiol.2022.1163544
Chicago: Humanities Style
Pereira, Gabriel, and Emily Pereira Dos Santos and Maria Augusta Ruy Barbosa and Sofía Tomaselli Arioni and Thabata Caroline De Oliveira Santos and Débora Tavares De Resende E Silva and Juan Sebastian Henao Agudelo and Maria Do Carmo Pinho Franco and Ricardo Fernandez and Rafael Luiz Pereira and Danilo Cândido De Almeida. “Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion.” European Journal of Biology 81, no. 2 (Dec. 2024): 274-280. https://doi.org/10.26650/EurJBiol.2022.1163544
Harvard: Australian Style
Pereira, G & Pereira Dos Santos, E & Ruy Barbosa, MA & Arioni, ST & De Oliveira Santos, TC & De Resende E Silva, DT & Henao Agudelo, JS & Pinho Franco, MD & Fernandez, R & Pereira, RL & De Almeida, DC 2022, 'Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion', European Journal of Biology, vol. 81, no. 2, pp. 274-280, viewed 23 Dec. 2024, https://doi.org/10.26650/EurJBiol.2022.1163544
Harvard: Author-Date Style
Pereira, G. and Pereira Dos Santos, E. and Ruy Barbosa, M.A. and Arioni, S.T. and De Oliveira Santos, T.C. and De Resende E Silva, D.T. and Henao Agudelo, J.S. and Pinho Franco, M.D. and Fernandez, R. and Pereira, R.L. and De Almeida, D.C. (2022) ‘Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion’, European Journal of Biology, 81(2), pp. 274-280. https://doi.org/10.26650/EurJBiol.2022.1163544 (23 Dec. 2024).
MLA
Pereira, Gabriel, and Emily Pereira Dos Santos and Maria Augusta Ruy Barbosa and Sofía Tomaselli Arioni and Thabata Caroline De Oliveira Santos and Débora Tavares De Resende E Silva and Juan Sebastian Henao Agudelo and Maria Do Carmo Pinho Franco and Ricardo Fernandez and Rafael Luiz Pereira and Danilo Cândido De Almeida. “Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion.” European Journal of Biology, vol. 81, no. 2, 2022, pp. 274-280. [Database Container], https://doi.org/10.26650/EurJBiol.2022.1163544
Vancouver
Pereira G, Pereira Dos Santos E, Ruy Barbosa MA, Arioni ST, De Oliveira Santos TC, De Resende E Silva DT, Henao Agudelo JS, Pinho Franco MD, Fernandez R, Pereira RL, De Almeida DC. Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion. European Journal of Biology [Internet]. 23 Dec. 2024 [cited 23 Dec. 2024];81(2):274-280. Available from: https://doi.org/10.26650/EurJBiol.2022.1163544 doi: 10.26650/EurJBiol.2022.1163544
ISNAD
Pereira, Gabriel - Pereira Dos Santos, Emily - Ruy Barbosa, MariaAugusta - Arioni, SofíaTomaselli - De Oliveira Santos, ThabataCaroline - De Resende E Silva, DéboraTavares - Henao Agudelo, JuanSebastian - Pinho Franco, MariaDo Carmo - Fernandez, Ricardo - Pereira, RafaelLuiz - De Almeida, DaniloCândido. “Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion”. European Journal of Biology 81/2 (Dec. 2024): 274-280. https://doi.org/10.26650/EurJBiol.2022.1163544