Review Article


DOI :10.26650/EurJBiol.2022.1163544   IUP :10.26650/EurJBiol.2022.1163544    Full Text (PDF)

Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion

Gabriel PereiraEmily Pereira Dos SantosMaria Augusta Ruy BarbosaSofía Tomaselli ArioniThabata Caroline De Oliveira SantosDébora Tavares De Resende E SilvaJuan Sebastian Henao AgudeloMaria Do Carmo Pinho FrancoRicardo FernandezRafael Luiz PereiraDanilo Cândido De Almeida

Chronic Kidney Disease (CKD) affects millions of people worldwide and is a global health problem with few treatment options. The mechanisms underlying the pathogenesis of CKD include oxidative damage and inflammation. Damage to the glomeruli may be observed during the course of co-associated diseases such diabetes, but also in specific conditions such as focal segmental glomerulosclerosis. During its early manifestation, podocyte’s damage and death are key factors to glomerulopathies and its protection may represent an important therapeutic approach. Importantly, podocytes pathology involves inflammation and cellular damage, principally due to excessive oxidative stress. Underlying mechanisms associated to both inflammation and oxidative stress during the course of a renal lesion must be elucidated for the development of better clinical and research approaches to kidney physiology. Thus, here we discuss the role of the Thioredoxin system, an antioxidant mechanism, and TXNIP, a thioredoxin inhibitor linked to NRLP3 inflammasome activation, as a pivotal axis in the pathophysiology of glomerular lesions.


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APA

Pereira, G., Pereira Dos Santos, E., Ruy Barbosa, M.A., Arioni, S.T., De Oliveira Santos, T.C., De Resende E Silva, D.T., Henao Agudelo, J.S., Pinho Franco, M.D., Fernandez, R., Pereira, R.L., & De Almeida, D.C. (2022). Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion. European Journal of Biology, 81(2), 274-280. https://doi.org/10.26650/EurJBiol.2022.1163544


AMA

Pereira G, Pereira Dos Santos E, Ruy Barbosa M A, Arioni S T, De Oliveira Santos T C, De Resende E Silva D T, Henao Agudelo J S, Pinho Franco M D, Fernandez R, Pereira R L, De Almeida D C. Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion. European Journal of Biology. 2022;81(2):274-280. https://doi.org/10.26650/EurJBiol.2022.1163544


ABNT

Pereira, G.; Pereira Dos Santos, E.; Ruy Barbosa, M.A.; Arioni, S.T.; De Oliveira Santos, T.C.; De Resende E Silva, D.T.; Henao Agudelo, J.S.; Pinho Franco, M.D.; Fernandez, R.; Pereira, R.L.; De Almeida, D.C. Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion. European Journal of Biology, [Publisher Location], v. 81, n. 2, p. 274-280, 2022.


Chicago: Author-Date Style

Pereira, Gabriel, and Emily Pereira Dos Santos and Maria Augusta Ruy Barbosa and Sofía Tomaselli Arioni and Thabata Caroline De Oliveira Santos and Débora Tavares De Resende E Silva and Juan Sebastian Henao Agudelo and Maria Do Carmo Pinho Franco and Ricardo Fernandez and Rafael Luiz Pereira and Danilo Cândido De Almeida. 2022. “Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion.” European Journal of Biology 81, no. 2: 274-280. https://doi.org/10.26650/EurJBiol.2022.1163544


Chicago: Humanities Style

Pereira, Gabriel, and Emily Pereira Dos Santos and Maria Augusta Ruy Barbosa and Sofía Tomaselli Arioni and Thabata Caroline De Oliveira Santos and Débora Tavares De Resende E Silva and Juan Sebastian Henao Agudelo and Maria Do Carmo Pinho Franco and Ricardo Fernandez and Rafael Luiz Pereira and Danilo Cândido De Almeida. Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion.” European Journal of Biology 81, no. 2 (Nov. 2024): 274-280. https://doi.org/10.26650/EurJBiol.2022.1163544


Harvard: Australian Style

Pereira, G & Pereira Dos Santos, E & Ruy Barbosa, MA & Arioni, ST & De Oliveira Santos, TC & De Resende E Silva, DT & Henao Agudelo, JS & Pinho Franco, MD & Fernandez, R & Pereira, RL & De Almeida, DC 2022, 'Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion', European Journal of Biology, vol. 81, no. 2, pp. 274-280, viewed 22 Nov. 2024, https://doi.org/10.26650/EurJBiol.2022.1163544


Harvard: Author-Date Style

Pereira, G. and Pereira Dos Santos, E. and Ruy Barbosa, M.A. and Arioni, S.T. and De Oliveira Santos, T.C. and De Resende E Silva, D.T. and Henao Agudelo, J.S. and Pinho Franco, M.D. and Fernandez, R. and Pereira, R.L. and De Almeida, D.C. (2022) ‘Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion’, European Journal of Biology, 81(2), pp. 274-280. https://doi.org/10.26650/EurJBiol.2022.1163544 (22 Nov. 2024).


MLA

Pereira, Gabriel, and Emily Pereira Dos Santos and Maria Augusta Ruy Barbosa and Sofía Tomaselli Arioni and Thabata Caroline De Oliveira Santos and Débora Tavares De Resende E Silva and Juan Sebastian Henao Agudelo and Maria Do Carmo Pinho Franco and Ricardo Fernandez and Rafael Luiz Pereira and Danilo Cândido De Almeida. Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion.” European Journal of Biology, vol. 81, no. 2, 2022, pp. 274-280. [Database Container], https://doi.org/10.26650/EurJBiol.2022.1163544


Vancouver

Pereira G, Pereira Dos Santos E, Ruy Barbosa MA, Arioni ST, De Oliveira Santos TC, De Resende E Silva DT, Henao Agudelo JS, Pinho Franco MD, Fernandez R, Pereira RL, De Almeida DC. Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion. European Journal of Biology [Internet]. 22 Nov. 2024 [cited 22 Nov. 2024];81(2):274-280. Available from: https://doi.org/10.26650/EurJBiol.2022.1163544 doi: 10.26650/EurJBiol.2022.1163544


ISNAD

Pereira, Gabriel - Pereira Dos Santos, Emily - Ruy Barbosa, MariaAugusta - Arioni, SofíaTomaselli - De Oliveira Santos, ThabataCaroline - De Resende E Silva, DéboraTavares - Henao Agudelo, JuanSebastian - Pinho Franco, MariaDo Carmo - Fernandez, Ricardo - Pereira, RafaelLuiz - De Almeida, DaniloCândido. Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion”. European Journal of Biology 81/2 (Nov. 2024): 274-280. https://doi.org/10.26650/EurJBiol.2022.1163544



TIMELINE


Submitted30.08.2022
Accepted19.10.2022
Published Online21.12.2022

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