European Journal of Biology

SUBMITINFORMATION
EnglishTürkçe

Research Article


DOI :10.26650/EurJBiol.2018.18008   IUP :10.26650/EurJBiol.2018.18008    Full Text (PDF)

Serum Concentration of Ghrelin, Oxidative Stress and Lipid Parameters in Obese Subjects

Sevilay Zora, Türkan Yigitbasi, Gozde Ulfer, Nesrin Emekli

Objective: Ghrelin is a hormone with peptide structure. It has fatty tissue and increases appetite. Obesity is a multifactorial chronic disease characterized by an increase in fat tissue. Fat tissue, like the endocrine organ, triggers oxidative stress and can lead to the development of obesity-related pathologies. The purpose of this study is to examine the relationship between the ghrelin in blood, and oxidative stress and lipid parameters. Materials and Methods: The study was conducted with 61 obese and 24 healthy individuals. Ghreline levels were measured using the ELISA method, while total antioxidant status (TAS) and oxidant status (TOS), triglyceride (TG), total cholesterol (TC), HDL-cholesterol (HDL-C) and LDL cholesterol (LDL-C) levels were measured using the photometric method. Results: A negative correlation was found between body mass index (BMI) and ghrelin levels in the obese group (p<0.05). But there was no significant difference of ghrelin levels in obese and control groups (p>0.05). TAS was observed to be lower in obese compared to control group, while The Oxidative Stress Index (OSI) was found to be significantly higher than the obese group (p<0.05). TG levels were found to be increased in obese; whereas ghrelin, TC, LDL-C and HDL-C levels did not show any difference (p>0.05). Conclusion: Increasing obesity level (BMI) and decreasing ghrelin level were found to be correlated. New studies are needed in order to discover the changes in ghrelin level connected to oxidative stress.
Keywords: Ghrelin, obesity, oxidative stress

PDF View

References

  • 1. Yiğitbaşı T, Emekli N. Obezite Biyokimyası. İçinde: Klinik Biyokimya, Editörler: Emekli & Yiğitbaşı, Akademi Basım Yayın, Yayımcı Nobel Tıp Kitabevleri 2015; 311-22. google scholar
  • 2. Sikaris KA. The clinical bichemistry of obesity. Clin Biochem Review 2004; 25(3): 165-81. google scholar
  • 3. Haslam D, Sattar N, Lean M. ABC of Obesity: obesity time to wake up. British Medical Journal 2014; 333(7569): 640-42. google scholar
  • 4. Murphy KG, Bloom SR. Gut hormones and regulation of energy hemeostasis. Nature 2006; 444(7121): 854-59. google scholar
  • 5. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001; 86(12): 5992. google scholar
  • 6. Noguerias R, Perez-Tilve D, Worrtley KE and Tschop M. Growth hormone secretagogue(ghrelin) receptors a complex drug target for the regulation of body weight. CNS Neurol Disord Drug Targets 2006; 5(3): 335-43. google scholar
  • 7. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth hormone releasing acylated peptide from stomach. Nature 1999; 402(6762): 656-60. google scholar
  • 8. Otto B, Cuntz U, Fruehauf E, Wawarta R, Fulwaczny C, Riepl RL, et al. Weight gain decreases elevated plasma ghrelin concentrations of patients with anoxia nervosa. Eur J Endocrinol 2001; 145(5): 669-73. google scholar
  • 9. Neary NM, Small CJ, Wren AM, Lee JL, Druce MR, Palmieri C et al. Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo controlled trial. J Clin Endocrinol Metab 2004;89(6): 2832-36. google scholar
  • 10. Kim KA, Yim JE. Antioxidative activity of onion peel extract in obese women: A randomized, double-blind, placebo controlelled study. J Cancer Prev 2015; 20(3): 202-7. google scholar
  • 11. Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, Watson AD, Lusis AJ. Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics. Circulation 1995; 91(9): 2488-96. google scholar
  • 12. Suematsu M, Katsuki A, Sumida Y, Gabazza EC, Murashima S, Matsumoto K, et al. Decreased circulating levels of active ghrelin are associated with increased oxidative stress in obese subjects. Eur J Endocrinol 2005; 153(3): 403-7. google scholar
  • 13. Hopps E, Noto D, Caim G, Averna MR. A novel component of the metabolic syndrome: The oxidative stress. Nutr Metab Cardiovasc Dis 2010; 20(1): 72-7. google scholar
  • 14. Oner-Iyidogan Y, Kocak H, Gurdol H, Oner P, Issever H, Esin D. Circulating ghrelin levels in obese women: a possible association with hypertension. Scand J Clin Lab Invest 2007; 67(5): 568-76. google scholar
  • 15. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005; 38(12): 1103-11. google scholar
  • 16. Chamber ES, Viardot A, Psichas A, Morrison DJ, Murphy KG, Zac-Varghese SEK, et al. Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Gut 2015; 64(11): 1744-54. google scholar
  • 17. Mucioli G, Tschöp M, Papotti M, Deghenghi R, Himen M, Ghigo E. Neuroendoncrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol 2003; 440(2-3): 235-54. google scholar
  • 18. Kara H. The relationship between weight loss and biochemical parameters such as leptin, ghrelin, nesfatin 1, obestatin in obese individuals. Balikesir University, Institute of Health Sciences, Department of Medical Biochemistry. Master Thesis, Balıkesir, 2014. google scholar
  • 19. Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001; 50(4): 707-9. google scholar
  • 20. Cinaz P, Yesilkaya E, Kaya A. Plasma ghrelin, serum IGF-1 and IGFBP-3 levels in obese children. J Ist Faculty Med 2009; 72 (2): 47-51. google scholar

Citations

Copy and paste a formatted citation or use one of the options to export in your chosen format


EXPORT



APA

Zora, S., Yigitbasi, T., Ulfer, G., & Emekli, N. (2018). Serum Concentration of Ghrelin, Oxidative Stress and Lipid Parameters in Obese Subjects. European Journal of Biology, 77(2), 55-58. https://doi.org/10.26650/EurJBiol.2018.18008


AMA

Zora S, Yigitbasi T, Ulfer G, Emekli N. Serum Concentration of Ghrelin, Oxidative Stress and Lipid Parameters in Obese Subjects. European Journal of Biology. 2018;77(2):55-58. https://doi.org/10.26650/EurJBiol.2018.18008


ABNT

Zora, S.; Yigitbasi, T.; Ulfer, G.; Emekli, N. Serum Concentration of Ghrelin, Oxidative Stress and Lipid Parameters in Obese Subjects. European Journal of Biology, [Publisher Location], v. 77, n. 2, p. 55-58, 2018.


Chicago: Author-Date Style

Zora, Sevilay, and Türkan Yigitbasi and Gozde Ulfer and Nesrin Emekli. 2018. “Serum Concentration of Ghrelin, Oxidative Stress and Lipid Parameters in Obese Subjects.” European Journal of Biology 77, no. 2: 55-58. https://doi.org/10.26650/EurJBiol.2018.18008


Chicago: Humanities Style

Zora, Sevilay, and Türkan Yigitbasi and Gozde Ulfer and Nesrin Emekli. “Serum Concentration of Ghrelin, Oxidative Stress and Lipid Parameters in Obese Subjects.” European Journal of Biology 77, no. 2 (Sep. 2025): 55-58. https://doi.org/10.26650/EurJBiol.2018.18008


Harvard: Australian Style

Zora, S & Yigitbasi, T & Ulfer, G & Emekli, N 2018, 'Serum Concentration of Ghrelin, Oxidative Stress and Lipid Parameters in Obese Subjects', European Journal of Biology, vol. 77, no. 2, pp. 55-58, viewed 20 Sep. 2025, https://doi.org/10.26650/EurJBiol.2018.18008


Harvard: Author-Date Style

Zora, S. and Yigitbasi, T. and Ulfer, G. and Emekli, N. (2018) ‘Serum Concentration of Ghrelin, Oxidative Stress and Lipid Parameters in Obese Subjects’, European Journal of Biology, 77(2), pp. 55-58. https://doi.org/10.26650/EurJBiol.2018.18008 (20 Sep. 2025).


MLA

Zora, Sevilay, and Türkan Yigitbasi and Gozde Ulfer and Nesrin Emekli. “Serum Concentration of Ghrelin, Oxidative Stress and Lipid Parameters in Obese Subjects.” European Journal of Biology, vol. 77, no. 2, 2018, pp. 55-58. [Database Container], https://doi.org/10.26650/EurJBiol.2018.18008


Vancouver

Zora S, Yigitbasi T, Ulfer G, Emekli N. Serum Concentration of Ghrelin, Oxidative Stress and Lipid Parameters in Obese Subjects. European Journal of Biology [Internet]. 20 Sep. 2025 [cited 20 Sep. 2025];77(2):55-58. Available from: https://doi.org/10.26650/EurJBiol.2018.18008 doi: 10.26650/EurJBiol.2018.18008


ISNAD

Zora, Sevilay - Yigitbasi, Türkan - Ulfer, Gozde - Emekli, Nesrin. “Serum Concentration of Ghrelin, Oxidative Stress and Lipid Parameters in Obese Subjects”. European Journal of Biology 77/2 (Sep. 2025): 55-58. https://doi.org/10.26650/EurJBiol.2018.18008



TIMELINE


Submitted12.07.2018
Accepted18.09.2018
Published Online02.12.2018

LICENCE


Attribution-NonCommercial (CC BY-NC)

This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


SHARE



Istanbul University Press aims to contribute to the dissemination of ever growing scientific knowledge through publication of high quality scientific journals and books in accordance with the international publishing standards and ethics. Istanbul University Press follows an open access, non-commercial, scholarly publishing.